The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2023-01-01 DOI:10.52547/rbmb.11.4.547

Reza Zare, Hamidreza Abdolsamadi, Sara Soleimani Asl, Shahrbanoo Radi, Hossein Bahrami, Shokoofeh Jamshidi

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引用次数: 1

Abstract

Background: The role of the basic fibroblast growth factor (bFGF) has well known in the angiogenesis and ulcer healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal wound.

Methods: Musosal wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days 3, 7 and 14 after the wound induction. The micro vessel density (MVD) and CD34 expression were done by histochemical studies.

Results: The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased 14 days after surgery. The MVD was significantly higher in the bFGF-treated group. The wound area was decreased in all groups time-dependently and a statistically significant difference (p value?) was observed between the bFGF-treated group and untreated group. The wound area was smaller in the bFGF-treated group compared to the untreated group.

Conclusions: Our data demonstrated that bFGF can accelerated and facilitated wound healing.

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bFGF能促进口腔黏膜血管生成，促进口腔创面愈合。

背景:碱性成纤维细胞生长因子(bFGF)在血管生成和溃疡愈合中的作用已广为人知。在这项研究中，我们旨在评估bFGF对大鼠口腔黏膜伤口组织修复的影响。方法:在大鼠唇黏膜上诱导粘膜创面，术后即刻沿粘膜缺损边缘注射bFGF。创面诱导后第3、7、14天采集组织。组织化学方法检测微血管密度(MVD)和CD34的表达。结果:bFGF显著促进肉芽组织形成，MVD在溃疡诱导后第3天升高，术后第14天降低。bfgf治疗组MVD明显增高。各组创面面积均随时间的变化而减小，bfgf治疗组与未治疗组间差异有统计学意义(p值)。与未治疗组相比，bfgf治疗组的伤口面积更小。结论:我们的数据表明bFGF可以加速和促进伤口愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.