Association Between Low-Density Lipoprotein-Cholesterol Level and Risk of Intracranial Atherosclerotic Stenosis: Results From the APAC Study.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Neurologist Pub Date : 2023-09-01 DOI:10.1097/NRL.0000000000000488

Yuan Shen, Jing Wang, Anxin Wang, Xingquan Zhao

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引用次数: 0

Abstract

Background: It is unknown whether plasma low-density lipoprotein-cholesterol level (LDL-C) can predict the occurrence of intracranial atherosclerotic stenosis (ICAS), especially asymptomatic (A)ICAS. This study investigated whether LDL-C level is independently associated with AICAS.

Methods: The Asymptomatic Polyvascular Abnormalities Community study is an ongoing community-based, prospective, long-term follow-up observational study with 3387 participants. AICAS was diagnosed by transcranial Doppler ultrasonography. The participants were divided into 3 groups based on LDL-C level. Cox regression was used to evaluate the association between LDL-C level and incidence of AICAS.

Results: During 2 years of follow-up, 9.98% of participants were diagnosed with AICAS. The incidence of AICAS (person-years with 95% CI) was 4.99% (4.48%-5.50%). AICAS incidence did not increase with increasing LDL-C level. Compared with the <2.6 mmol/l subgroup, the incidence of asymptomatic ICAS was not significantly higher in the 2.6 to 3.4 and >3.4 mmol/l subgroups after adjusting for confounding factors (hazard ratio=0.95, 95% CI: 0.86-1.03 and hazard ratio=0.96, 95% CI: 0.84-1.10, respectively).

Conclusions: LDL-C is not an independent predictor of AICAS incidence in the Chinese population.

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低密度脂蛋白胆固醇水平与颅内动脉粥样硬化性狭窄风险之间的关系：APAC研究结果。

背景：目前尚不清楚血浆低密度脂蛋白胆固醇水平（LDL-C）是否能预测颅内动脉粥样硬化性狭窄（ICAS），尤其是无症状（A）ICAS的发生。本研究调查了LDL-C水平是否与AICAS独立相关。方法：无症状多血管异常社区研究是一项基于社区的前瞻性长期随访观察性研究，共有3387名参与者。经颅多普勒超声诊断为AICAS。根据LDL-C水平将参与者分为3组。采用Cox回归法评估LDL-C水平与AICAS发生率之间的关系。结果：在2年的随访中，9.98%的参与者被诊断为AICAS。AICAS的发生率为4.99%（4.48%-5.50%），AICAS的发病率不随LDL-C水平的升高而增加。在校正混杂因素后，与3.4mmol/l亚组进行比较（危险比分别为0.95、95%CI:0.86-1.03和0.96、95%CI:0.84-1.00）。结论：LDL-C不是中国人群AICAS发病率的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.