Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals.

IF 2.1 Q3 CLINICAL NEUROLOGY
Anna Perkiö, Ilona Merikanto, Katri Kantojärvi, Tiina Paunio, Nasa Sinnott-Armstrong, Samuel E Jones, Hanna M Ollila
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引用次数: 1

Abstract

Polygenic risk scores (PRSs) estimate genetic liability for diseases and traits. However, the portability of PRSs in sleep traits has remained elusive. We generated PRSs for self-reported insomnia, chronotype and sleep duration using summary data from genome-wide association studies (GWASs) performed in 350,000 to 697,000 European-ancestry individuals. We then projected the scores in two independent Finnish population cohorts (N = 33,493) and tested whether the PRSs were associated with their respective sleep traits. We observed that all the generated PRSs were associated with their corresponding traits (p < 0.05 in all cases). Furthermore, we found that there was a 22.2 min difference in reported sleep between the 5% tails of the PRS for sleep duration (p < 0.001). Our findings indicate that sleep-related PRSs show portability across cohorts. The findings also demonstrate that sleep measures using PRSs for sleep behaviors may provide useful instruments for testing disease and trait associations in cohorts where direct sleep parameters have not yet been measured.

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33493人睡眠时间、失眠和生物钟多基因风险评分的可移植性
多基因风险评分(PRSs)评估疾病和性状的遗传倾向性。然而,PRSs在睡眠特征中的可移植性仍然难以捉摸。我们使用来自35万至69.7万欧洲血统个体的全基因组关联研究(GWASs)的汇总数据,生成了自我报告的失眠、睡眠类型和睡眠时间的prs。然后,我们在两个独立的芬兰人群队列(N = 33,493)中预测得分,并测试PRSs是否与各自的睡眠特征相关。我们观察到所有产生的PRSs与其相应的性状相关(p < 0.05)。此外,我们发现,在睡眠持续时间的PRS的5%尾部之间,报告的睡眠时间差异为22.2分钟(p < 0.001)。我们的研究结果表明,睡眠相关的PRSs在人群中具有可移植性。研究结果还表明,在尚未测量直接睡眠参数的人群中,使用PRSs测量睡眠行为可能为测试疾病和特征关联提供有用的工具。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
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审稿时长
7 weeks
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