Utility of optical coherence tomography in patients of central immune mediated demyelinating diseases – A prospective study

Q3 Neuroscience

eNeurologicalSci Pub Date : 2023-06-01 DOI:10.1016/j.ensci.2023.100464

Monalisa Vegda , Samhita Panda , Kavita R. Bhatnagar

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引用次数: 0

Abstract

Optical coherence tomography (OCT) is a non-invasive tool to measure thickness of various layers of retina. Recently, retinal nerve fibre layer (RNFL) and ganglion cell and inner plexiform layer (GCIP) thinning has been observed in OCT in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), This study compared OCT profile, along with visual acuity (VA), color vision (CV), contrast saturation (CS) and visual evoked potentials (VEP) in two main cohorts of MS and NMOSD and with controls, during acute episode of optic neuritis (ON), at 3 and 6 months.

We found that changes of ON were present in 75% of MS eyes and in 45% of NMOSD patients. Of these, subclinical involvement was present in 56.25% of MS eyes and only in 5% of NMOSD eyes suggesting frequent subclinical involvement in the former. Mean RNFL was 95.23 ± 15.53 in MS and 66.14 ± 43.73 in NMOSD after 6 months of ON episode. Thinning of NQ and IQ was observed in NMOSD eyes in the immediate period after ON attack. At 6 months relative sparing of RNFL in TQ was observed in NMOSD ON eyes and MS ON showed predilection for involvement of TQ.

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光学相干断层扫描在中枢免疫介导的脱髓鞘疾病患者中的应用——一项前瞻性研究

光学相干断层扫描（OCT）是一种测量视网膜各层厚度的非侵入性工具。最近，在多发性硬化（MS）和视神经脊髓炎谱系障碍（NMOSD）患者的OCT中观察到视网膜神经纤维层（RNFL）、神经节细胞和内丛状层（GCIP）变薄，在急性视神经炎（ON）发作的3个月和6个月时，MS和NMOSD两个主要队列以及对照组的对比度饱和度（CS）和视觉诱发电位（VEP）。我们发现75%的MS眼和45%的NMOSD患者存在ON变化。其中，56.25%的MS眼和仅5%的NMOSD眼存在亚临床受累，表明前者存在频繁的亚临床受累。ON发作6个月后，MS和NMOSD的平均RNFL分别为95.23±15.53和66.14±43.73。在ON发作后立即观察到NMOSD眼睛的NQ和IQ变薄。在6个月时，NMOSD-ON眼观察到RNFL在TQ中的相对保留，并且MS-ON显示出参与TQ的偏好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

期刊介绍： eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.