Attention/Deficit Hyperactivity Disorder in Adolescent and Young Adult Males With Fragile X Syndrome.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-05-01 DOI:10.1352/1944-7558-127.3.213

Jessica Klusek, Shannon L O'Connor, Alexandra Hickey, Kimberly J Hills, Leonard Abbeduto, Jane E Roberts

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Abstract

This study characterized the rates of attention-deficit/hyperactivity disorder (ADHD) in adolescent and young adult males with fragile X syndrome (FXS) using a multi-method approach integrating a DSM-based parent interview (Children's Interview for Psychiatric Syndromes; P-ChIPS, Fristad et al., 1998) and a parent rating scale (Child Behavior Checklist; CBCL, Achenbach, 2001). Thirty-one males with FXS, aged 16-24 years, participated. Forty-two percent met DSM-5 criteria for ADHD and 35% exceeded the CBCL cut-offs. Agreement between the two classification methods was fair (κ = 0.38). Autism symptom severity and nonverbal cognitive ability did not predict ADHD diagnoses/symptoms. Results show high rates of ADHD in males with FXS during late adolescence and young adulthood, which are not accounted for by impaired nonverbal cognitive skills or autism symptom severity. DSM-based ADHD-specific scales are recommended over broadband symptom scales to improve accurate identification.

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青少年和青年男性脆性 X 综合征患者的注意力/缺陷多动障碍。

本研究采用多种方法，综合了基于 DSM 的家长访谈（儿童精神综合征访谈；P-ChIPS，Fristad 等人，1998 年）和家长评分量表（儿童行为检查表；CBCL，Achenbach，2001 年），对患有脆性 X 综合征（FXS）的青少年和年轻成年男性的注意力缺陷/多动障碍（ADHD）发病率进行了描述。31 名患有 FXS 的男性参加了此次研究，他们的年龄在 16-24 岁之间。其中 42% 符合 DSM-5 多动症标准，35% 超过 CBCL 临界值。两种分类方法的一致性尚可（κ = 0.38）。自闭症症状严重程度和非语言认知能力并不能预测多动症的诊断/症状。研究结果表明，FXS 男性患者在青春后期和青年期的多动症发病率较高，而非语言认知能力受损或自闭症症状严重程度并不能解释这一点。建议使用基于DSM的ADHD特异性量表，而不是宽带症状量表，以提高识别的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.