Quantitative Meta-analyses of Cognitive Abilities in Children With Pediatric-onset Multiple Sclerosis.

IF 5.4 2区心理学 Q1 NEUROSCIENCES

Neuropsychology Review Pub Date : 2023-06-01 DOI:10.1007/s11065-022-09546-3

Elena S Lysenko, Mariia D Bogdanova, Marie Arsalidou

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引用次数: 1

Abstract

Pediatric-onset multiple sclerosis (POMS), is the manifestation of multiple sclerosis in individuals before 18 years of age. About a third of children with POMS show some form of lower cognitive performance. The purpose of this study is to examine using quantitative meta-analyses the effect size of altered performance between children with and without POMS on overall intelligence quotient (IQ), information processing speed, and language functions. We searched the literature for studies that reported scores on cognitive tests administered to children with and without POMS. Studies were systematically reviewed using PRISMA guidelines. We analyzed data from 14 studies that examined 1283 children with and without POMS when cognitive categories consisted of five or more studies. Effect sizes, publication bias and potential confounds were considered. Significant cognitive differences are revealed for all categories with the strongest effect observed for overall IQ. A moderate effect is observed for information processing speed, and small effects for verbal fluency and verbal memory. Cognitive abilities present differently in children with POMS and a better understanding of this manifestation will inform intervention and remediation tools that can improve clinical and educational practice for the benefit of children with POMS.

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儿童期多发性硬化症患儿认知能力的定量荟萃分析。

小儿起病多发性硬化症(POMS)，是18岁前个体多发性硬化症的表现。大约三分之一患有POMS的儿童表现出某种形式的认知能力下降。本研究的目的是通过定量荟萃分析来检验POMS患儿和非POMS患儿在整体智商、信息处理速度和语言功能上的影响大小。我们检索了文献，研究报告了对患有和不患有POMS的儿童进行的认知测试得分。使用PRISMA指南系统地审查了研究。我们分析了14项研究的数据，这些研究调查了1283名有或没有POMS的儿童，当认知类别包括5项或更多研究时。考虑了效应量、发表偏倚和潜在混淆。在所有类别中都发现了显著的认知差异，其中对整体智商的影响最大。对信息处理速度有中等程度的影响，对言语流畅性和言语记忆的影响较小。认知能力在POMS儿童中表现出不同的表现，更好地了解这种表现将为干预和补救工具提供信息，从而改善POMS儿童的临床和教育实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology Review 医学-神经科学

CiteScore

11.00

自引率

1.70%

发文量

期刊介绍： Neuropsychology Review is a quarterly, refereed publication devoted to integrative review papers on substantive content areas in neuropsychology, with particular focus on populations with endogenous or acquired conditions affecting brain and function and on translational research providing a mechanistic understanding of clinical problems. Publication of new data is not the purview of the journal. Articles are written by international specialists in the field, discussing such complex issues as distinctive functional features of central nervous system disease and injury; challenges in early diagnosis; the impact of genes and environment on function; risk factors for functional impairment; treatment efficacy of neuropsychological rehabilitation; the role of neuroimaging, neuroelectrophysiology, and other neurometric modalities in explicating function; clinical trial design; neuropsychological function and its substrates characteristic of normal development and aging; and neuropsychological dysfunction and its substrates in neurological, psychiatric, and medical conditions. The journal''s broad perspective is supported by an outstanding, multidisciplinary editorial review board guided by the aim to provide students and professionals, clinicians and researchers with scholarly articles that critically and objectively summarize and synthesize the strengths and weaknesses in the literature and propose novel hypotheses, methods of analysis, and links to other fields.