Infections caused by hypervirulent Klebsiella pneumoniae in non-endemic countries: three case reports and review of the literature.

IF 1.6 4区 医学 Q2 Medicine
Wannes Van Hooste, Marthe Vanrentergem, Eric Nulens, Christophe Snauwaert, Deborah De Geyter, Rembert Mertens, Jens T Van Praet
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引用次数: 2

Abstract

Objectives: Spontaneous liver abscess caused by a hypervirulent Klebsiella pneumoniae strain was first described several decades ago in Taiwan and has been an emerging clinical entity worldwide ever since. We aimed to describe the clinical and microbiological characteristics of this infection in a non-endemic setting.

Methods: A narrative literature review was conducted in PubMed for European case reports of hypervirulent Klebsiella pneumoniae from 2016 to 2021.

Results: Forty case reports were retrieved. Mean age of the patients was 59 years and 72% were male. Diabetes mellitus was present in 33%. Twenty percent of the patients originated from an endemic region. A liver abscess and bacteremia were observed in, respectively, 83% and 80% of the cases. The most frequent metastatic infections were found in the eye (28%) and the lungs (28%). The sensitivity of molecular capsular antigen detection and the string test was 87% and 92%, respectively. Sixty-three percent of the strains had a wildtype resistance.

Conclusion: Hypervirulent Klebsiella pneumoniae infections in non-endemic countries are most frequently observed in middle-aged males. Clinicians should be vigilant for metastatic infections.

在非流行国家由高毒力肺炎克雷伯菌引起的感染:三个病例报告和文献综述。
目的:由高毒力肺炎克雷伯菌引起的自发性肝脓肿,几十年前在台湾首次被发现,此后在世界范围内已成为一种新兴的临床实体。我们的目的是描述非地方性环境下这种感染的临床和微生物学特征。方法:在PubMed上对2016 - 2021年欧洲高致病性肺炎克雷伯菌病例报告进行叙述性文献回顾。结果:共检索到40例病例报告。患者平均年龄59岁,男性占72%。33%的患者有糖尿病。20%的患者来自流行地区。肝脓肿和菌血症发生率分别为83%和80%。最常见的转移性感染是眼部(28%)和肺部(28%)。分子包膜抗原检测和串法检测的灵敏度分别为87%和92%。63%的菌株具有野生型抗性。结论:高毒力肺炎克雷伯菌感染在非流行国家最常见于中年男性。临床医生应警惕转移性感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica 医学-医学:内科
CiteScore
2.90
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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