Teriparatide treatment shows faster healing than sacroplasty for postmenopausal women with sacral insufficiency fracture

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia Pub Date : 2023-03-01 DOI:10.1016/j.afos.2023.02.001

Yao-Chun Yang , Min-Hong Hsieh , Jui-Teng Chien , Keng-Chang Liu , Chang-Chen Yang

{"title":"Teriparatide treatment shows faster healing than sacroplasty for postmenopausal women with sacral insufficiency fracture","authors":"Yao-Chun Yang , Min-Hong Hsieh , Jui-Teng Chien , Keng-Chang Liu , Chang-Chen Yang","doi":"10.1016/j.afos.2023.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF.</p></div><div><h3>Methods</h3><p>Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed.</p></div><div><h3>Results</h3><p>The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment.</p></div><div><h3>Conclusions</h3><p>Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 1","pages":"Pages 27-31"},"PeriodicalIF":2.5000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111959/pdf/main.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteoporosis and Sarcopenia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405525523000018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 1

Abstract

Objectives

Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF.

Methods

Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed.

Results

The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment.

Conclusions

Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.

查看原文本刊更多论文

特立帕肽治疗绝经后骶骨功能不全骨折比骶骨成形术愈合更快

目的老年人骨不全性骨折（SIF）是一种常见的骨质疏松性骨折。除了传统的治疗方法外，还引入了骶成形术和特立帕肽（TPTD）注射。本报告旨在比较骶成形术和特立帕肽对SIF临床结果的影响。方法对31例老年SIF患者进行回顾性观察研究。四名男性患者被排除在外。14名接受TPTD治疗6个月的患者被分为TPTD组（TT），13名接受骶成形术的患者被划分为骶成形术组（SS）。两组的所有患者都被要求每天补充钙和维生素D。对他们的症状和体征、视觉模拟评分（VAS）、奥斯韦斯特里残疾指数（ODI）和放射学研究进行回顾性审查。结果TT组在治疗3个月（P＜0.001）和6个月（P＜0.001）后VAS评分显著低于SS组，在治疗1个月（P=0.010）、3个月、6个月后ODI评分也明显低于SS组（P＜0.005）。根据广义估计方程（GEE）分析，与SS组相比，TT组在治疗后1个月（P=0.022，P=0.001）、3个月（P<；0.001，P<；001）和6个月（P<；0.001，P/lt；0.001）的VAS和ODI均显著降低。结论经TPTD治疗的绝经后SIF患者在治疗1个月后的愈合情况优于经骶成形术的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology

自引率

5.00%

发文量

审稿时长

66 days