Long-term expansion of human hematopoietic stem cells.

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2023-04-19 DOI:10.1186/s13619-023-00163-w

Guixian Liang, Feng Liu

引用次数: 0

Abstract

Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human HSCs ex vivo, Sakurai et al. established a recombinant-cytokine-free and albumin-free culture system, i.e. PCL-PVAc-PEG-based culture, in combination with 740Y-P, butyzamide and UM171, to improve the long-term expansion of human cord blood HSCs.

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人类造血干细胞的长期扩增。

造血干细胞(hsc)是治疗多种血液系统疾病的关键。然而，造血干细胞数量少，导致临床应用困难。为了在体外获得更多功能的人造血干细胞，Sakurai等人建立了一种无重组细胞因子和无白蛋白的培养体系，即基于pcl - pvac - peg的培养体系，与740Y-P、丁酰胺和UM171联合培养，以提高人脐带血造血干细胞的长期扩增能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine