Microneedle Device Delivering Aggregation-Induced Emission Photosensitizers for Enhanced Metronomic Photodynamic Therapy of Cancer

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2023-03-26 DOI:10.1021/acsami.3c01682

Jun Dai, Simin Wei, Jiarong Xu, Huiying Xue, Zhaojun Chen, Meng Wu, Wei Chen*, Xiaoding Lou, Fan Xia* and Shixuan Wang*,

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引用次数: 2

Abstract

Metronomic photodynamic therapy (mPDT), which induces cancer cell death by prolonged intermittent continuous irradiation at lower light power, has profoundly promising applications. However, the photobleaching sensitivity of the photosensitizer (PS) and the difficulty of delivery pose barriers to the clinical application of mPDT. Here, we constructed a microneedle-based device (Microneedles@AIE PSs) that combined with aggregation-induced emission (AIE) PSs to achieve enhanced mPDT for cancer. Due to the strong anti-photobleaching property of the AIE PS, it can maintain superior photosensitivity even after long-time light exposure. The delivery of the AIE PS to the tumor through a microneedle device allows for greater uniformity and depth. This Microneedles@AIE PSs-based mPDT (M-mPDT) offers better treatment outcomes and easier access, and combining M-mPDT with surgery or immunotherapy can also significantly improve the effectiveness of these clinical therapies. In conclusion, M-mPDT offers a promising strategy for the clinical application of PDT due to its better efficacy and convenience.

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微针装置提供聚集体诱导发射光敏剂用于增强癌症的节律光动力治疗

节律光动力疗法(mPDT)是一种在较低光功率下通过长时间间歇连续照射诱导癌细胞死亡的方法，具有广泛的应用前景。然而，光敏剂(PS)的光漂白敏感性和给药困难对mPDT的临床应用构成了障碍。在这里，我们构建了一个基于微针的装置(Microneedles@AIE PSs)，结合聚集诱导发射(AIE) PSs来实现对癌症的增强mPDT。由于AIE PS具有很强的抗光漂白性能，即使在长时间的光照下也能保持优越的光敏性。通过微针装置将AIE PS输送到肿瘤中，可以获得更大的均匀性和深度。这种Microneedles@AIE基于pss的mPDT (M-mPDT)提供了更好的治疗效果和更容易获得，并且将M-mPDT与手术或免疫治疗相结合也可以显着提高这些临床治疗的有效性。综上所述，M-mPDT因其更好的疗效和便便性，为PDT的临床应用提供了一个很有前景的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.