The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2023-03-26 DOI:10.1002/mrd.23683

Adrian Guzmán, Cyndi G. Hernández-Coronado, Carlos G. Gutiérrez, Ana M. Rosales-Torres

{"title":"The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth","authors":"Adrian Guzmán, Cyndi G. Hernández-Coronado, Carlos G. Gutiérrez, Ana M. Rosales-Torres","doi":"10.1002/mrd.23683","DOIUrl":null,"url":null,"abstract":"<p>The vascular endothelial growth factor-A (VEGFA) system is a complex set of proteins, with multiple isoforms and receptors, including both angiogenic (VEGFxxx, VEGFR2) and antiangiogenic members (VEGFxxxb, VEGFR1 and soluble forms of VEGFR). The members of the VEGF system affect the proliferation, survival, and migration of endothelial and nonendothelial cells and are involved in the regulation of follicular angiogenesis and development. The production of VEGF by secondary follicles stimulates preantral follicular development by directly affecting follicular cells and promoting the acquisition of the follicular vasculature and downstream antrum formation. Additionally, the pattern of expression of the components of the VEGF system may provide a proangiogenic milieu capable of triggering angiogenesis and stimulating follicular cells to promote antral follicle growth, whereas, during atresia, this milieu becomes antiangiogenic and blocks follicular development.</p>","PeriodicalId":18856,"journal":{"name":"Molecular Reproduction and Development","volume":"90 4","pages":"201-217"},"PeriodicalIF":2.7000,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrd.23683","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Reproduction and Development","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mrd.23683","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

The vascular endothelial growth factor-A (VEGFA) system is a complex set of proteins, with multiple isoforms and receptors, including both angiogenic (VEGFxxx, VEGFR2) and antiangiogenic members (VEGFxxxb, VEGFR1 and soluble forms of VEGFR). The members of the VEGF system affect the proliferation, survival, and migration of endothelial and nonendothelial cells and are involved in the regulation of follicular angiogenesis and development. The production of VEGF by secondary follicles stimulates preantral follicular development by directly affecting follicular cells and promoting the acquisition of the follicular vasculature and downstream antrum formation. Additionally, the pattern of expression of the components of the VEGF system may provide a proangiogenic milieu capable of triggering angiogenesis and stimulating follicular cells to promote antral follicle growth, whereas, during atresia, this milieu becomes antiangiogenic and blocks follicular development.

Abstract Image

查看原文本刊更多论文

血管内皮生长因子(VEGF)系统是卵巢卵泡血管生成和生长的关键调节因子

血管内皮生长因子- a (VEGFA)系统是一组复杂的蛋白质，具有多种异构体和受体，包括血管生成(VEGFxxx, VEGFR2)和抗血管生成成员(VEGFxxxb, VEGFR1和VEGFR的可溶性形式)。VEGF系统的成员影响内皮细胞和非内皮细胞的增殖、存活和迁移，并参与滤泡血管生成和发育的调节。次生滤泡产生VEGF，通过直接影响滤泡细胞，促进滤泡血管的获取和下游腔的形成，从而刺激腔前滤泡的发育。此外，VEGF系统成分的表达模式可能提供了一种促血管生成环境，能够触发血管生成并刺激滤泡细胞以促进窦泡生长，然而，在闭锁期间，这种环境变得抗血管生成并阻碍滤泡发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.