Comparison of ⁶⁸GA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT findings in peritonitis carcinomatosa cases.

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2023-01-01 DOI:10.1967/s002449912553

Yunus Güzel, İhsan Kaplan

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引用次数: 2

Abstract

Objective: This study was conducted to compare the diagnostic accuracy of gallium-68-radiolabeled fibroblast activation protein inhibitor (⁶⁸Ga-FAPI-04), positron emission tomography/computed tomography (PET/CT), and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET/CT based on the peritoneal carcinomatosis (PC) index for detecting peritoneal metastases of various cancer types, and to evaluate the potential benefits of FAPI PET/CT in patients with peritoneal metastases.

Subjects and methods: This retrospective study included 57 patients with peritoneal metastases between November 2020 and December 2021. All patients underwent ⁶⁸Ga-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT scans within 7 days.

Results: Among the 57 patients included, 32 (56.1%) were male and the median age was 54 years (22-86 years). In the visual evaluation made from a total of 13 quadrants on the abdominopelvic peritoneal surfaces, positive findings were observed in 111 quadrants in 39 patients by ¹⁸F-FDG PET/CT and in 280 quadrants in 57 patients by ⁶⁸Ga-FAPI-04 PET/CT (P<0.001). The maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR) values of ⁶⁸Ga-FAPI-04 PET/CT for the PC lesions were significantly higher than the SUVmax and TBR values of ¹⁸F-FDG PET/CT in all patients and in all quadrants (SUVmax 6.45 vs 4.1; P<0.001; TBR 14.9 vs 6.8; P<0.001).

Conclusion: Gallium-68-FAPI-04 PET/CT showed superior sensitivity compared to ¹⁸F-FDG PET/CT in both quantitative and visual evaluations of PC. Considering the low background activity and higher specific activity uptake values, ⁶⁸Ga-FAPI-04 PET/CT helped improve diagnostic accuracy.

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68GA-FAPI-04 PET/CT与18F-FDG PET/CT在腹膜炎癌样病变中的比较

目的:本研究比较基于腹膜癌(PC)指数的镓-68放射性标记成纤维细胞活化蛋白抑制剂(68Ga-FAPI-04)、正电子发射断层扫描/计算机断层扫描(PET/CT)和氟-18-氟脱氧葡萄糖(18F-FDG) PET/CT对各种癌症类型腹膜转移的诊断准确性，并评价FAPI PET/CT对腹膜转移患者的潜在益处。对象和方法:该回顾性研究包括57例2020年11月至2021年12月期间腹膜转移的患者。所有患者均在7天内进行了68Ga-FAPI-04 PET/CT和18F-FDG PET/CT扫描。结果:57例患者中，男性32例(56.1%)，中位年龄54岁(22 ~ 86岁)。在对腹腔腹膜表面共13个象限进行的视觉评估中，39例患者的18F-FDG PET/CT在111个象限中观察到阳性结果，57例患者的68Ga-FAPI-04 PET/CT在280个象限中观察到阳性结果(PC病变的P68Ga-FAPI-04 PET/CT在所有患者和所有象限中均显著高于18F-FDG PET/CT的SUVmax和TBR值(SUVmax 6.45 vs 4.1;结论:镓-68- fapi -04 PET/CT对PC的定量和视觉评价均优于18F-FDG PET/CT。考虑到低背景活度和较高的比活性摄取值，68Ga-FAPI-04 PET/CT有助于提高诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.