A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets.

IF 2.3 Q3 CLINICAL NEUROLOGY
Klaus Schmierer, Heinz Wiendl, Celia Oreja-Guevara, Diego Centonze, Anita Chudecka, Sanjeev Roy, Ursula Boschert
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Abstract

What is this summary about?: This is a summary of an article originally published in the Multiple Sclerosis Journal. Cladribine tablets (MAVENCLAD®) are an oral (taken by mouth) medication, approved for the treatment of people with relapsing forms of multiple sclerosis (MS, with episodes of new or worsening symptoms). They are administered for a maximum of 10 days per year, over a period of 2 years. Cladribine tablets work by temporarily reducing the number of lymphocytes, which are immune cells that help to fight off infections. Because of this, people with MS (also called PwMS) may have concerns about the effect of cladribine tablets on vaccines, as these work via immune cells to build protection against infection.

What happened in the magnify-ms study?: A study called MAGNIFY-MS investigated how long it takes for cladribine tablets to begin to work in people with a type of MS called highly active relapsing MS. During the study, some participants received their usual vaccinations against flu (influenza) and against the chickenpox virus (also called varicella zoster virus) as part of their routine medical care. The MAGNIFY-MS study gave the researchers an opportunity to look at how cladribine tablets affect the way the flu and chickenpox virus vaccines work in the body.

What were the results?: Cladribine tablets do not affect how well the body responds to flu and chickenpox vaccines.

What do the results mean?: PwMS taking cladribine tablets who are vaccinated against chickenpox, flu or both can be protected against these diseases.

用克拉德里滨片治疗多发性硬化症患者,对流感和水痘疫苗的影响的简单语言总结。
这个总结是关于什么的?这是最初发表在《多发性硬化症杂志》上的一篇文章的摘要。Cladribine片剂(MAVENCLAD®)是一种口服(口服)药物,被批准用于治疗复发型多发性硬化症(MS)患者,伴有新症状发作或症状恶化。它们每年最多使用10天,为期2年。克拉宾片剂的作用是暂时减少淋巴细胞的数量,淋巴细胞是帮助抵抗感染的免疫细胞。正因为如此,患有多发性硬化症(也称为PwMS)的人可能会担心克拉德里滨片对疫苗的影响,因为这些疫苗是通过免疫细胞来建立防止感染的保护的。在放大质谱研究中发生了什么?当前位置一项名为“MAGNIFY-MS”的研究调查了克拉德宾片剂对一种名为“高活性复发性多发性硬化症”的多发性硬化症患者需要多长时间才能开始起作用。在研究期间,一些参与者接受了常规的流感(流感)和水痘病毒(也称为水痘带状疱疹病毒)疫苗接种,这是他们日常医疗保健的一部分。MAGNIFY-MS研究为研究人员提供了一个观察克拉德滨片如何影响流感和水痘病毒疫苗在体内的作用的机会。结果如何?克拉宾片剂不会影响人体对流感和水痘疫苗的反应。这些结果意味着什么?服用克拉德滨片剂的妇女接种过水痘、流感或两者的疫苗,可预防这些疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
4.30
自引率
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35
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