Molecular Mechanisms of Dendritic Spine Development and Plasticity.

Abstract

Dendritic spines were first described by Santiago Ramon y Cajal more than one hundred years ago when he examined Golgi-stained cerebellar Purkinje cells of birds. Since then, considerable effort has been put towards understanding how these structures are formed and what their functions in the central nervous system are. It is now well established that dendritic spines represent specialized subcellular compartments on the postsynaptic neuron where the majority of excitatory synapses are located. Therefore, the density of dendritic spines is a rough indication of how much excitatory input a particular neuron receives. One notable feature of these structures is the large heterogeneity of their dimensions and shapes. They can exist as short stubby spines, long thin spines, and mushroom-shaped spines. Moreover, they are highly dynamic, such that ongoing spine growth, turnover, and morphological changes occur in both developing and adult brains. Although excitatory synapses can form and function outside of dendritic spines, their location on spine heads likely confers additional properties. For example, the presence of the spine neck is thought to create an isolated biochemical compartment on the spine head, where individual synapses of the postsynaptic neuron can function and be regulated independently of each other. Changes in the dimension and shape of individual spines also allow modulation of synaptic efficacy between specific neuronal partners and therefore contribute to synaptic plasticity and provide the cellular basis of learning and memory. Indeed, many molecular players that regulate dendritic spine morphogenesis also turn out to be essential for learning-related synaptic plasticity and memory formation. In this special issue, reviews and original research papers have been collected to address various questions on dendritic spine biology. These include the process of spine development, the functional differentiation of large and small spines, the relationships between spine changes and learning, the signaling pathways that control spine morphogenesis, and the link between spine abnormalities and brain disorders.