Efficient Preparation of a Magnetic Helical Carbon Nanomotor for Targeted Anticancer Drug Delivery

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY
Yanming Sun, Renjie Pan, Yuduo Chen, Yong Wang, Lei Sun, Neng Wang, Xing Ma* and Guo Ping Wang*, 
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引用次数: 3

Abstract

The applications of nanomotors in the biomedical field have been attracting extensive attention. However, it remains a challenge to fabricate nanomotors in a facile way and effectively load drugs for active targeted therapy. In this work, we combine the microwave heating method and chemical vapor deposition (CVD) to fabricate magnetic helical nanomotors efficiently. The microwave heating method can accelerate intermolecular movement, which converts kinetic energy into heat energy and shortens the preparation time of the catalyst used for carbon nanocoil (CNC) synthesis by 15 times. Fe3O4 nanoparticles are in situ nucleated on the CNC surface by the microwave heating method to fabricate magnetically driven CNC/Fe3O4 nanomotors. In addition, we achieved precise control of the magnetically driven CNC/Fe3O4 nanomotors through remote manipulation of magnetic fields. Anticancer drug doxorubicin (DOX) is then efficiently loaded onto the nanomotors via π–π stacking interactions. Finally, the drug-loaded CNC/Fe3O4@DOX nanomotor can accurately accomplish cell targeting under external magnetic field control. Under short-time irradiation of near-infrared light, DOX can be quickly released onto target cells to effectively kill the cells. More importantly, CNC/Fe3O4@DOX nanomotors allow for single-cell or cell-cluster-targeted anticancer drug delivery, providing a dexterous platform to potentially perform many medically relevant tasks in vivo. The efficient preparation method and application in drug delivery are beneficial for future industrial production and provide inspiration for advanced micro/nanorobotic systems using the CNC as a carrier for a wide range of biomedical applications.

Abstract Image

用于靶向抗癌药物递送的磁性螺旋碳纳米马达的高效制备
纳米电机在生物医学领域的应用引起了人们的广泛关注。然而,以一种简单的方式制造纳米马达并有效地装载用于主动靶向治疗的药物仍然是一个挑战。在这项工作中,我们将微波加热方法和化学气相沉积(CVD)相结合,有效地制备了磁性螺旋纳米电机。微波加热方法可以加速分子间运动,将动能转化为热能,并将用于碳纳米线圈(CNC)合成的催化剂的制备时间缩短15倍。采用微波加热的方法在CNC表面原位成核Fe3O4纳米颗粒,制备了磁驱动的CNC/Fe3O4纳米粒子电机。此外,我们还通过磁场的远程操作实现了对磁驱动CNC/Fe3O4纳米电机的精确控制。抗癌药物阿霉素(DOX)通过π–π堆叠相互作用有效地负载到纳米马达上。最后,装有药物的CNC/Fe3O4@DOX纳米电机可以在外部磁场控制下准确地实现细胞靶向。在近红外光的短时间照射下,DOX可以快速释放到靶细胞上,有效杀死细胞。更重要的是,CNC/Fe3O4@DOX纳米马达允许单细胞或细胞簇靶向抗癌药物递送,为在体内执行许多医学相关任务提供了一个灵活的平台。高效的制备方法和在药物递送中的应用有利于未来的工业生产,并为使用CNC作为载体的先进微/纳米机器人系统提供了灵感,用于广泛的生物医学应用。
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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
发文量
0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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