Glycometabolism reprogramming: Implications for cardiovascular diseases

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2023-05-01 DOI:10.1016/j.pbiomolbio.2023.03.003

Guolong Peng , Jialong Yan , Linxi Chen, Lanfang Li

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引用次数: 2

Abstract

Glycometabolism is well known for its roles as the main source of energy, which mainly includes three metabolic pathways: oxidative phosphorylation, glycolysis and pentose phosphate pathway. The orderly progress of glycometabolism is the basis for the maintenance of cardiovascular function. However, upon exposure to harmful stimuli, the intracellular glycometabolism changes or tends to shift toward another glycometabolism pathway more suitable for its own development and adaptation. This shift away from the normal glycometabolism is also known as glycometabolism reprogramming, which is commonly related to the occurrence and aggravation of cardiovascular diseases. In this review, we elucidate the physiological role of glycometabolism in the cardiovascular system and summarize the mechanisms by which glycometabolism drives cardiovascular diseases, including diabetes, cardiac hypertrophy, heart failure, atherosclerosis, and pulmonary hypertension. Collectively, directing GMR back to normal glycometabolism might provide a therapeutic strategy for the prevention and treatment of related cardiovascular diseases.

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糖代谢重编程：对心血管疾病的影响

糖代谢是众所周知的主要能量来源，主要包括三种代谢途径：氧化磷酸化、糖酵解和磷酸戊糖途径。糖代谢的有序进行是维持心血管功能的基础。然而，在暴露于有害刺激后，细胞内糖代谢发生变化或倾向于转向另一种更适合其自身发育和适应的糖代谢途径。这种偏离正常糖代谢的转变也被称为糖代谢重编程，通常与心血管疾病的发生和加重有关。在这篇综述中，我们阐明了糖代谢在心血管系统中的生理作用，并总结了糖代谢驱动心血管疾病的机制，包括糖尿病、心肌肥大、心力衰竭、动脉粥样硬化和肺动脉高压。总之，引导GMR恢复正常的糖代谢可能为预防和治疗相关心血管疾病提供一种治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567