Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea

IF 6.7 Q1 ENGINEERING, ENVIRONMENTAL
Nguyen Thanh Tung, Shang-Yang Lin, Wen-Te Liu, Yi-Chun Kuan, Chih-Da Wu, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Tran Phan Chung Thuy and Hsiao-Chi Chuang*, 
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引用次数: 0

Abstract

We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM2.5) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM2.5 was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m3) of PM2.5 was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA (p < 0.05). We observed that a 1 μg/m3 increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) (p < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region (p < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA.

Abstract Image

阻塞性睡眠呼吸暂停患者肺泡区高颗粒物沉积可加速体脂堆积
我们进行了一项横断面研究,以调查空气动力学直径小于2.5μm的颗粒物(PM)和PM沉积与阻塞性睡眠呼吸暂停(OSA)患者夜间身体成分变化的关系。生物电阻抗分析用于测量185名OSA患者睡眠前和睡眠后的身体成分。PM2.5的年暴露量通过混合克里格/土地利用回归模型进行估算。采用多路径粒子剂量测定模型来估计肺部PM沉积。我们观察到PM2.5四分位间距(IQR)(1μg/m3)的增加与OSA右臂脂肪百分比增加20.1%和右臂脂肪量增加0.012kg有关(p<0.05)右臂脂肪百分比和脂肪质量变化的增加(β系数)(p<0.05);头部和鼻腔区域>;气管支气管区域>;总肺区(p<0.05)。我们的研究结果表明,肺区,特别是肺泡区PM沉积的增加可能与右臂脂肪百分比和脂肪质量的夜间变化有关。肺泡区PM沉积可加速OSA患者体内脂肪的积累。
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来源期刊
ACS Environmental Au
ACS Environmental Au 环境科学-
CiteScore
7.10
自引率
0.00%
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0
期刊介绍: ACS Environmental Au is an open access journal which publishes experimental research and theoretical results in all aspects of environmental science and technology both pure and applied. Short letters comprehensive articles reviews and perspectives are welcome in the following areas:Alternative EnergyAnthropogenic Impacts on Atmosphere Soil or WaterBiogeochemical CyclingBiomass or Wastes as ResourcesContaminants in Aquatic and Terrestrial EnvironmentsEnvironmental Data ScienceEcotoxicology and Public HealthEnergy and ClimateEnvironmental Modeling Processes and Measurement Methods and TechnologiesEnvironmental Nanotechnology and BiotechnologyGreen ChemistryGreen Manufacturing and EngineeringRisk assessment Regulatory Frameworks and Life-Cycle AssessmentsTreatment and Resource Recovery and Waste Management
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