Cell Death Pathways: The Variable Mechanisms Underlying Fine Particulate Matter-Induced Cytotoxicity

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY
Yucai Chen, Yue Wu, Yu Qi* and Sijin Liu, 
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引用次数: 4

Abstract

Recently, the advent of health risks due to the cytotoxicity of fine particulate matter (FPM) is concerning. Numerous studies have reported abundant data elucidating the FPM-induced cell death pathways. However, several challenges and knowledge gaps are still confronted nowadays. On one hand, the undefined components of FPM (such as heavy metals, polycyclic aromatic hydrocarbons, and pathogens) are all responsible for detrimental effects, thus rendering it difficult to delineate the specific roles of these copollutants. On the other hand, owing to the crosstalk and interplay among different cell death signaling pathways, precisely determining the threats and risks posed by FPM is difficult. Herein, we recapitulate the current knowledge gaps present in the recent studies regarding FPM-induced cell death, and propose future research directions for policy-making to prevent FPM-induced diseases and improve knowledge concerning the adverse outcome pathways and public health risks of FPM.

Abstract Image

细胞死亡途径:细颗粒物诱导的细胞毒性的可变机制
最近,细颗粒物(FPM)的细胞毒性导致的健康风险的出现令人担忧。大量研究报道了大量阐明FPM诱导的细胞死亡途径的数据。然而,今天仍然面临着一些挑战和知识差距。一方面,FPM的未定义成分(如重金属、多环芳烃和病原体)都是造成有害影响的原因,因此很难确定这些污染物的具体作用。另一方面,由于不同细胞死亡信号通路之间的串扰和相互作用,很难准确确定FPM带来的威胁和风险。在此,我们总结了最近关于FPM诱导的细胞死亡的研究中存在的知识空白,并提出了未来的研究方向,以预防FPM诱导疾病,提高对FPM不良后果途径和公共健康风险的认识。
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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
发文量
0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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