The Emerging Role of CircRNAs in Atherosclerosis.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Jing Yang, Shuling Rong
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引用次数: 1

Abstract

Cardiovascular diseases (CVDs) based on atherosclerosis remain the main reason for death in Western countries and China. Cardiovascular research has demonstrated that its pathogenesis is closely associated with endothelial cell (EC) injury, the phenotypic transformation of vascular smooth muscle cells (VSMCs), and the abnormal biological behaviour of macrophages. In recent years, circular RNAs (circRNAs) have received much attention for their unique role in the pathogenesis of atherosclerosis. In this review, we discussed the mechanisms associated with ECs, VSMCs, and macrophages in atherosclerosis and summarized the role of circRNAs in atherosclerosis. This review aims to provide a basis for the prevention and treatment of atherosclerosis.

环状rna在动脉粥样硬化中的新作用。
以动脉粥样硬化为基础的心血管疾病(cvd)仍然是西方国家和中国死亡的主要原因。心血管研究表明其发病机制与内皮细胞(EC)损伤、血管平滑肌细胞(VSMCs)表型转化以及巨噬细胞异常生物学行为密切相关。近年来,环状rna (circRNAs)因其在动脉粥样硬化发病机制中的独特作用而备受关注。在这篇综述中,我们讨论了内皮细胞、VSMCs和巨噬细胞在动脉粥样硬化中的相关机制,并总结了环状rna在动脉粥样硬化中的作用。本文旨在为动脉粥样硬化的预防和治疗提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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