Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Aspects of Medicine Pub Date : 2023-06-01 DOI:10.1016/j.mam.2022.101167

Marissa N. Russo , Lauren A. Whaley , Emily S. Norton , Natanael Zarco , Hugo Guerrero-Cázares

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引用次数: 1

Abstract

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.

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胶质母细胞瘤微环境中的细胞外小泡：诊断和治疗前景

胶质母细胞瘤（GBM）是胶质瘤中最恶性的一种，也是成人最常见、最致命的原发性脑肿瘤。传统的癌症治疗对GBM的疗效有限。GBM细胞对被称为肿瘤微环境（TME）的周围脑实质做出反应并适应，以促进肿瘤的保存。在特定的TME中，有3个对GBM生物学特别感兴趣：血管周围生态位、室下区神经源性生态位和免疫微环境。GBM细胞和TME细胞呈现相互反馈，导致肿瘤维持。这些细胞通讯的一种方式是通过细胞外小泡。这些囊泡包括外泌体和微泡，它们能够携带癌性和非癌性货物，如miRNA、RNA、蛋白质、脂质和DNA。在这篇综述中，我们将讨论细胞外小泡这一蓬勃发展的话题，以及它们如何具有作为GBM诊断和靶向载体的新颖性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.