Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review.

IF 8.4 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-02-28 DOI:10.1007/s12016-022-08957-7
Zhouxian Pan, Yimin Dai, Nicole Akar-Ghibril, Jessica Simpson, Huali Ren, Lishan Zhang, Yibo Hou, Xueyi Wen, Christopher Chang, Rui Tang, Jin-Lyu Sun
{"title":"Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review.","authors":"Zhouxian Pan,&nbsp;Yimin Dai,&nbsp;Nicole Akar-Ghibril,&nbsp;Jessica Simpson,&nbsp;Huali Ren,&nbsp;Lishan Zhang,&nbsp;Yibo Hou,&nbsp;Xueyi Wen,&nbsp;Christopher Chang,&nbsp;Rui Tang,&nbsp;Jin-Lyu Sun","doi":"10.1007/s12016-022-08957-7","DOIUrl":null,"url":null,"abstract":"<p><p>Air pollution is associated with multiple health problems worldwide, contributing to increased morbidity and mortality. Atopic dermatitis (AD) is a common allergic disease, and increasing evidence has revealed a role of air pollution in the development of atopic dermatitis. Air pollutants are derived from several sources, including harmful gases such as nitrogen dioxide (NO<sub>2</sub>), sulfur dioxide (SO<sub>2</sub>), and carbon monoxide (CO), as well as particulate matter (PM) of various sizes, and bioaerosols. Possible mechanisms linking air pollution to atopic dermatitis include damage to the skin barrier through oxidative stress, increased water loss, physicochemical injury, and an effect on skin microflora. Furthermore, oxidative stress triggers immune dysregulation, leading to enhanced sensitization to allergens. There have been multiple studies focusing on the association between various types of air pollutants and atopic dermatitis. Since there are many confounders in the current research, such as climate, synergistic effects of mixed pollutants, and diversity of study population, it is not surprising that inconsistencies exist between different studies regarding AD and air pollution. Still, it is generally accepted that air pollution is a risk factor for AD. Future studies should focus on how air pollution leads to AD as well as effective intervention measures.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":null,"pages":null},"PeriodicalIF":8.4000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Reviews in Allergy & Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12016-022-08957-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 5

Abstract

Air pollution is associated with multiple health problems worldwide, contributing to increased morbidity and mortality. Atopic dermatitis (AD) is a common allergic disease, and increasing evidence has revealed a role of air pollution in the development of atopic dermatitis. Air pollutants are derived from several sources, including harmful gases such as nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO), as well as particulate matter (PM) of various sizes, and bioaerosols. Possible mechanisms linking air pollution to atopic dermatitis include damage to the skin barrier through oxidative stress, increased water loss, physicochemical injury, and an effect on skin microflora. Furthermore, oxidative stress triggers immune dysregulation, leading to enhanced sensitization to allergens. There have been multiple studies focusing on the association between various types of air pollutants and atopic dermatitis. Since there are many confounders in the current research, such as climate, synergistic effects of mixed pollutants, and diversity of study population, it is not surprising that inconsistencies exist between different studies regarding AD and air pollution. Still, it is generally accepted that air pollution is a risk factor for AD. Future studies should focus on how air pollution leads to AD as well as effective intervention measures.

Abstract Image

空气污染对特应性皮炎的影响:综述。
空气污染与世界各地的多种健康问题有关,导致发病率和死亡率增加。特应性皮炎(AD)是一种常见的过敏性疾病,越来越多的证据表明空气污染在特应性皮肤炎的发展中起着作用。空气污染物来自多种来源,包括二氧化氮(NO2)、二氧化硫(SO2)和一氧化碳(CO)等有害气体,以及各种大小的颗粒物(PM)和生物气溶胶。将空气污染与特应性皮炎联系起来的可能机制包括氧化应激对皮肤屏障的损害、水分损失增加、物理化学损伤以及对皮肤微生物群落的影响。此外,氧化应激会引发免疫失调,从而增强对过敏原的敏感性。已有多项研究关注各种类型的空气污染物与特应性皮炎之间的关系。由于当前的研究中存在许多混杂因素,如气候、混合污染物的协同效应和研究人群的多样性,因此关于AD和空气污染的不同研究之间存在不一致也就不足为奇了。尽管如此,人们普遍认为空气污染是AD的一个风险因素。未来的研究应该集中在空气污染如何导致AD以及有效的干预措施上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信