Post-weaning social isolation increases the incentive value of nicotine-related contexts and decreases the accumulation of ΔFosB in nucleus accumbens in adolescent rats

IF 3.3 3区心理学 Q1 BEHAVIORAL SCIENCES

Pharmacology Biochemistry and Behavior Pub Date : 2023-02-01 DOI:10.1016/j.pbb.2023.173529

Diana M. Cortés-Patiño, Hans Ballesteros-Acosta, Valentyna Martin Neira, David Rikardo Pérez Contreras, Marisol R. Lamprea

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引用次数: 2

Abstract

Adolescent social conditions profoundly affect vulnerability to drug abuse. Preclinical studies have shown that preventing social interactions during adolescence increases the rewarding effects of drugs like alcohol, cocaine, or amphetamines, however, little data exist regarding the impact of social isolation on nicotine effects. The current study evaluated the effects of differential rearing conditions during adolescence (isolation or group rearing) on (1) conditioned place preference induced by low nicotine doses (0.1 or 0.3 mg/kg) and (2) sensitization to the locomotor effects of nicotine after sub-chronic administration (3) and accumulation of ΔFosB in nucleus accumbens (NAc). Results showed that nicotine induced place preference in isolated and grouped rats, but the effect was more persistent for the rats reared in isolation. Isolated reared rats also exhibited lower levels of ΔFosB accumulation in NAc. No differences were found in the behavioral sensitization to nicotine effects between rearing conditions. The results suggest that isolation engenders a more robust incentive value of nicotine-related contexts. This effect could be related to the basal expression of ΔFosB: lower levels of this transcription factor seem to impair the motivation of isolated reared rats and increase their vulnerability to the effects of drugs like nicotine.

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断奶后的社会隔离增加了尼古丁相关环境的激励价值，减少了青春期大鼠伏隔核ΔFosB的积累

青少年的社会条件深刻地影响着吸毒的脆弱性。临床前研究表明，在青春期预防社交会增加酒精、可卡因或安非他命等药物的奖励作用，然而，关于社交隔离对尼古丁影响的影响，几乎没有数据。目前的研究评估了青春期不同养育条件（隔离或集体养育）对（1）低尼古丁剂量（0.1或0.3 mg/kg）诱导的条件性场所偏好和（2）亚慢性给药后对尼古丁运动效应的敏感性的影响（3）以及ΔFosB在伏隔核（NAc）中的积累。结果表明，尼古丁在隔离和分组大鼠中诱导了位置偏好，但在隔离饲养的大鼠中这种影响更持久。分离饲养的大鼠在NAc中也表现出较低水平的ΔFosB积累。在不同饲养条件下，对尼古丁影响的行为敏化没有发现差异。研究结果表明，与尼古丁相关的环境中，隔离会产生更强大的激励价值。这种影响可能与ΔFosB的基础表达有关：较低水平的这种转录因子似乎会削弱隔离饲养的大鼠的动机，并增加它们对尼古丁等药物影响的脆弱性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacology Biochemistry and Behavior 医学-行为科学

CiteScore

6.40

自引率

2.80%

发文量

122

审稿时长

38 days

期刊介绍： Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.