The relationship between cadmium and cognition in the elderly: a systematic review.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2168755

Xueke Yang, Lijing Xi, Zhaoyan Guo, Li Liu, Zhiguang Ping

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引用次数: 0

Abstract

Context: The relationship between cadmium (Cd) and the cognition of the elderly is indistinct.Objective: To summarise the studies on the relationship between the cognition of the elderly and Cd.Methods: Literatures were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan fang database on April 25, 2022. The entries in the STROBE statement were used to evaluate the literature quality; all the quantitative studies that met the requirements were systematically summarised.Results: Blood Cd was negatively correlated with the cognitive ability of the elderly, corresponding to different cognitive ability assessment methods, the regression coefficients were: -0.11 (-0.20, -0.03), -0.46 (-0.71, -0.21), -0.54 (-0.90, -0.17), -0.19 (-0.37, -0.01), and -2.29 (-3.41, -1.16). The regression coefficients between urinary Cd level and cognition score were -1.42 (-2.38, -0.46), and 0.76 (-1.28, -0.23). When dietary Cd increased by 1 μg/kg, the composite z-score decreased by 3.64 (p = 0.001). There was no significant correlation between drinking water Cd, fingernail Cd and cognition (p > 0.05).Conclusion: We concluded that blood Cd (including whole blood and plasma), urine Cd and dietary Cd were negatively correlated with the cognition of the elderly, but the relationship between Cd in drinking water and fingernails and cognition was not statistically significant.

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镉与老年人认知的关系:一项系统综述。

背景:镉(Cd)与老年人认知的关系尚不明确。目的:总结老年人认知与cd关系的研究。方法:检索PubMed、Web of Science、中国知网(CNKI)和万方数据库，检索时间为2022年4月25日。采用STROBE语句中的条目评价文献质量;系统总结了所有符合要求的定量研究。结果:血Cd与老年人认知能力呈负相关，对应不同认知能力评估方法，回归系数分别为-0.11(-0.20，-0.03)、-0.46(-0.71，-0.21)、-0.54(-0.90，-0.17)、-0.19(-0.37，-0.01)、-2.29(-3.41，-1.16)。尿Cd水平与认知评分的回归系数分别为-1.42(-2.38，-0.46)和0.76(-1.28，-0.23)。饲粮镉每增加1 μg/kg，复合z评分降低3.64分(p = 0.001)。饮水Cd、指甲Cd与认知无显著相关(p > 0.05)。结论:血Cd(包括全血和血浆)、尿Cd和膳食Cd与老年人认知水平呈负相关，而饮用水和指甲中Cd与认知水平的关系无统计学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.