The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection.

IF 8 1区生物学 Q1 MICROBIOLOGY

Microbiology and Molecular Biology Reviews Pub Date : 2022-06-15 Epub Date: 2022-04-20 DOI:10.1128/mmbr.00110-21

Aric N Brown, Mark T Anderson, Michael A Bachman, Harry L T Mobley

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Abstract

ArcAB, also known as the Arc system, is a member of the two-component system family of bacterial transcriptional regulators and is composed of sensor kinase ArcB and response regulator ArcA. In this review, we describe the structure and function of these proteins and assess the state of the literature regarding ArcAB as a sensor of oxygen consumption. The bacterial quinone pool is the primary modulator of ArcAB activity, but questions remain for how this regulation occurs. This review highlights the role of quinones and their oxidation state in activating and deactivating ArcB and compares competing models of the regulatory mechanism. The cellular processes linked to ArcAB regulation of central metabolic pathways and potential interactions of the Arc system with other regulatory systems are also reviewed. Recent evidence for the function of ArcAB under aerobic conditions is challenging the long-standing characterization of this system as strictly an anaerobic global regulator, and the support for additional ArcAB functionality in this context is explored. Lastly, ArcAB-controlled cellular processes with relevance to infection are assessed.

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ArcAB 双组分系统：新陈代谢、氧化还原控制和感染中的功能

ArcAB 又称 Arc 系统，是细菌转录调节器双组分系统家族的成员，由传感器激酶 ArcB 和响应调节器 ArcA 组成。在这篇综述中，我们描述了这些蛋白质的结构和功能，并评估了有关 ArcAB 作为耗氧传感器的文献现状。细菌醌池是 ArcAB 活性的主要调节器，但这种调节是如何发生的仍存在疑问。这篇综述强调了醌及其氧化状态在激活和失活 ArcB 中的作用，并比较了相互竞争的调控机制模型。此外，还综述了与 ArcAB 对中央代谢途径的调控有关的细胞过程，以及 Arc 系统与其他调控系统的潜在相互作用。最近有证据表明 ArcAB 在有氧条件下的功能，这对长期以来将该系统严格定性为厌氧全局调控因子的观点提出了挑战，并探讨了 ArcAB 在这种情况下的其他功能的支持情况。最后，评估了 ArcAB 控制的与感染有关的细胞过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.