The latest role of nerve-specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons.

IF 6.4 2区生物学 Q1 CELL BIOLOGY

Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-03-01 DOI:10.1002/wrna.1740

Xing-Dong Chen, Hui-Lin Liu, Sen Li, Kai-Bin Hu, Qing-Yun Wu, Ping Liao, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang

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引用次数: 3

Abstract

Central nervous system injury diseases can cause the loss of many neurons, and it is difficult to regenerate. The field of regenerative medicine believes that supplementing the missing neurons may be an ideal method for nerve injury repair. Recent studies have found that down-regulation of polypyrimidine tract binding protein 1 (PTBP1) expression can make glial cells transdifferentiate into different types of neurons, which is expected to be an alternative therapy to restore neuronal function. This article summarized the research progress on the structure and biological function of the PTBP family, the mutual regulation of PTBP1 and PTBP2, their role in neurogenesis, and the latest research progress in targeting PTBP1 to mediate the transdifferentiation of glial cells into neurons, which may provide some new strategies and new ideas for the future treatment of central nervous system injury and neurodegenerative diseases. This article is categorized under: RNA Processing > Splicing Regulation/Alternative Splicing.

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神经特异性剪接因子PTBP1在胶质细胞转分化为神经元中的最新作用。

中枢神经系统损伤性疾病可引起许多神经元的丧失，并且难以再生。再生医学界认为，补充缺失的神经元可能是修复神经损伤的理想方法。近期研究发现，下调多嘧啶束结合蛋白1 (PTBP1)表达可使胶质细胞转分化为不同类型的神经元，有望成为恢复神经元功能的替代疗法。本文综述了PTBP家族的结构和生物学功能、PTBP1和PTBP2的相互调控及其在神经发生中的作用等方面的研究进展，以及靶向PTBP1介导胶质细胞向神经元转分化的最新研究进展，以期为今后中枢神经系统损伤和神经退行性疾病的治疗提供一些新策略和新思路。本文分类如下:RNA加工>剪接调控/选择性剪接。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiley Interdisciplinary Reviews: RNA CELL BIOLOGY-

CiteScore

14.80

自引率

4.10%

发文量

审稿时长

6-12 weeks

期刊介绍： WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.