Prognostic Value of Systemic Inflammation Score for Esophageal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis.

IF 3.5 4区医学 Q2 SURGERY

Journal of Investigative Surgery Pub Date : 2023-12-01 DOI:10.1080/08941939.2023.2197058

Lingfang Shi, Xiufang Wang, Chungen Yan

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引用次数: 0

Abstract

Objective: The link between inflammation and cancer survival has been the subject of substantial research. The goal of this review is to summarize the evidence on the prognostic value of systemic inflammation score (SIS) in esophageal cancer patients undergoing surgical intervention.

Methods: PubMed, Scopus, Embase, and Web of Science were searched for relevant articles published until 30^th June 2022. We pooled adjusted data on overall survival (OS) and disease-free survival (DFS) using a random-effects meta-analysis model. The review was pre-registered on PROSPER (No. CRD42022340717).

Results: Eight studies were included. All studies were conducted either in China or Japan. Six studies showed that patients with SIS of 1-2 had poor OS as compared to those with scores of 0 (HR:1.42 95% CI: 1.24, 1.62 I²=25%). SIS of 1 (HR:1.45 95% CI: 1.18, 1.78 I²=0%) and 2 (HR:1.94 95% CI: 1.49, 2.53 I²=0%) were also associated with poor OS. Two studies compared the SIS score of 2 vs 0-1. Meta-analysis indicated that poor OS was associated with SIS of 2 (HR:1.80 95% CI: 1.25, 2.58). Data from three studies showed that the SIS score did not predict DFS (HR:1.40 95% CI: 0.82, 2.39 I²=91%).

Conclusion: SIS can be a novel prognostic indicator for esophageal cancer patients undergoing surgical intervention. Higher SIS is associated with a poor OS, but it does not predict DFS. Future studies are needed to strengthen the current evidence.

查看原文本刊更多论文

食管癌手术患者全身炎症评分的预后价值:系统回顾和荟萃分析。

目的：炎症与癌症生存之间的联系一直是大量研究的主题。本综述的目的是总结全身炎症评分（SIS）对接受手术干预的食管癌症患者的预后价值的证据。方法：检索PubMed、Scopus、Embase和Web of Science截至2022年6月30日发表的相关文章。我们使用随机效应荟萃分析模型汇总了总生存率（OS）和无病生存率（DFS）的调整数据。该综述已在PROSPER上预先注册（编号CRD42022340717）。结果：包括8项研究。所有研究均在中国或日本进行。六项研究表明，与评分为0的患者相比，SIS为1-2的患者OS较差（HR:1.42 95%CI:1.24，1.62 I2=25%）。1（HR:1.45 95%CI:1.18，1.78 I2=0%）和2（HR:1.94 95%CI:1.49，2.53 I2=0%）的SIS也与不良OS相关。两项研究比较了SIS评分为2分与0-1分。Meta-analysis表明OS差与2的SIS相关（HR:1.80 95%CI:1.25，2.58）。三项研究的数据表明，SIS评分不能预测DFS（HR:1.40 95%CI:0.82，2.39 I2=91%）。较高的SIS与较差的操作系统有关，但它不能预测DFS。未来的研究需要加强现有的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative Surgery 医学-外科

CiteScore

4.20

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.