It comes from the sea: macroalgae-derived bioactive compounds with anti-cancer potential.

IF 8.1 2区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-26 DOI:10.1080/07388551.2023.2174068

Paulo Nova, Ana Maria Gomes, Ana R Costa-Pinto

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引用次数: 0

Abstract

Nature derived compounds represent a valuable source of bioactive molecules with enormous potential. The sea is one of the richest environments, full of skilled organisms, where algae stand out due to their unique characteristics. Marine macroalgae adapt their phenotypic characteristics, such as chemical composition, depending on the environmental conditions where they live. The compounds produced by these organisms show tremendous potential to be used in the biomedical field, due to their antioxidant, anti-inflammatory, immunomodulatory, and anti-cancer properties.Cancer is one of the deadliest diseases in the world, and the lack of effective treatments highlights the urgent need for the development of new therapeutic strategies. This review provides an overview of the current advances regarding the anti-cancer activity of the three major groups of marine macroalgae, i.e., red algae (Rhodophyta), brown algae (Phaeophyceae), and green algae (Chlorophyta) on pancreatic, lung, breast, cervical, colorectal, liver, and gastric cancers as well as leukemia and melanoma. In addition, future perspectives, and limitations regarding this field of work are also discussed.

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它来自海洋：从大型藻类中提取的生物活性化合物具有抗癌潜力。

从大自然中提取的化合物是具有巨大潜力的生物活性分子的宝贵来源。海洋是最丰富的环境之一，其中充满了技术娴熟的生物，藻类因其独特的特性而脱颖而出。海洋大型藻类会根据其生活的环境条件调整其表型特征，如化学成分。这些生物产生的化合物具有抗氧化、抗炎、免疫调节和抗癌等特性，因此在生物医学领域具有巨大的应用潜力。癌症是世界上最致命的疾病之一，由于缺乏有效的治疗方法，因此迫切需要开发新的治疗策略。本综述概述了三大类海洋大型藻类，即红藻（红藻门）、褐藻（褐藻纲）和绿藻（绿藻门）对胰腺癌、肺癌、乳腺癌、宫颈癌、结直肠癌、肝癌、胃癌以及白血病和黑色素瘤的抗癌活性的最新进展。此外，还讨论了这一领域工作的未来前景和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物

CiteScore

20.80

自引率

1.10%

发文量

审稿时长

4.8 months

期刊介绍： Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.