The prevalence and treatment patterns of familial hypercholesterolemia among Thai patients with premature coronary artery disease.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medicine Pub Date : 2023-05-01 DOI:10.1080/00325481.2023.2182579

Nantiya Nawaka, Chutima Rattanawan, Burabha Pussadhamma, Atthakorn Wutthimanop, Manit Nuinoon, Sureerut Porntadavity, Watcharinthon Theansun, Nutjaree Jeenduang

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引用次数: 0

Abstract

Objectives: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that is characterized by severe hypercholesterolemia. The prevalence of FH in Thailand has not been reported. Therefore, this study aimed to investigate the prevalence of FH and treatment patterns among Thai patients with premature coronary artery disease (pCAD).

Methods: A total of 1,180 pCAD patients at two heart centers from northeastern and southern Thailand between October 2018 and September 2020 were enrolled. FH was diagnosed using the Dutch Lipid Clinic Network (DLCN) criteria. pCAD was diagnosed in men aged < 55 years and women aged < 60 years.

Results: The prevalence of definite/probable FH, possible FH, and unlikely FH in pCAD patients was 1.36% (n = 16), 24.83% (n = 293), and 73.81% (n = 871), respectively. Definite/probable FH in pCAD patients had a significantly higher frequency of STEMI but a lower frequency of hypertension than those with unlikely FH. After discharge, most pCAD patients (95.51%) received statin therapy. Definite/probable FH patients had a higher frequency of high-intensity statin therapy than those with possible FH and unlikely FH. After follow-up for 3-6 months, approximately 54.72% of pCAD patients with DLCN scores ≥ 5 had a reduction in LDL-C > 50% from baseline.

Conclusions: The prevalence of definite/probable FH, particularly possible FH, was high among pCAD patients in this study. The early diagnosis of FH among Thai pCAD patients should be performed for the early treatment and prevention of CAD.

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泰国早发冠心病患者家族性高胆固醇血症的患病率及治疗模式

目的:家族性高胆固醇血症(FH)是一种常染色体显性遗传病，以严重的高胆固醇血症为特征。目前尚未报告泰国的FH流行情况。因此，本研究旨在调查FH在泰国过早冠状动脉疾病(pCAD)患者中的患病率和治疗模式。方法:2018年10月至2020年9月，在泰国东北部和南部的两个心脏中心共招募了1180名pad患者。FH的诊断采用荷兰脂质临床网络(DLCN)标准。结果:pCAD患者确诊/可能FH、可能FH、不可能FH的患病率分别为1.36% (n = 16)、24.83% (n = 293)、73.81% (n = 871)。确诊/疑似FH的pCAD患者发生STEMI的频率明显高于未确诊FH的患者，但发生高血压的频率较低。出院后，大多数pCAD患者(95.51%)接受他汀类药物治疗。明确/可能的FH患者比可能的FH和不太可能的FH患者接受高强度他汀类药物治疗的频率更高。随访3-6个月后，约54.72% DLCN评分≥5的pCAD患者LDL-C较基线降低> 50%。结论:本研究中，确诊/可能的FH，特别是可能的FH，在pCAD患者中患病率很高。泰国pCAD患者中FH的早期诊断应用于CAD的早期治疗和预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medicine 医学-医学：内科

CiteScore

6.10

自引率

2.40%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916, Postgraduate Medicine was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.