Effect of comorbid benign joint hypermobility and juvenile fibromyalgia syndromes on pediatric functional gastrointestinal disorders.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medicine Pub Date : 2023-05-01 DOI:10.1080/00325481.2023.2176637

Nilüfer Ülkü Şahin, Nihal Şahin, Merve Kılıç

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引用次数: 2

Abstract

Objectives: Musculoskeletal pain has a considerable frequency in pediatric outpatients. Benign joint hypermobility (BJHS) and juvenile fibromyalgia syndrome (JFMS) are non-inflammatory causes of musculoskeletal pain. In these syndromes, pain is often accompanied by various symptoms such as fatigue, sleep difficulties, mood disorders, cognitive dysfunction, dizziness, headaches, abdominal pain, irritable bowel syndrome, and restless legs syndrome. Functional dyspepsia, functional vomiting, functional abdominal pain, functional constipation, and irritable bowel syndrome all together are termed functional gastrointestinal (GI) disorders. We aimed to evaluate the functional gastrointestinal disorders association of BJHS and JFMS.

Methods: Patients aged 10-18 years who were diagnosed with functional GI disorder in the pediatric gastroenterology department were included in the study. The findings of BJHS and JFMS were evaluated by the pediatric rheumatology department. Scales for anxiety, somatization, and depression were administered by a child psychiatrist. COMPASS 31 scoring was used in autonomic dysfunction.

Results: The prevalence of JFMS and BJHS was 64% and 32%, respectively in children with a functional GI disorder. Retrosternal chest pain, dysphagia, early satiation, nausea, vomiting, and regurgitation were common in JFMS (p = 0.007; p = 0.005; p = 0.018; p = 0.002, p = 0.013; p = 0.014, respectively). Gastrointestinal symptoms did not differ with BJHS. One hundred six (88.3%) and 99 (82.5%) had orthostatic intolerance and reflex syncope, respectively. One hundred three (85.6%) had anxiety symptoms, 101 (84.2%) had somatization symptoms, and 102 (85%) had depression symptoms.

Conclusions: Functional GI disorders, JFMS, and BJHS are complex intertwined disorders influenced by emotional distress. Therefore, a multidisciplinary approach is necessary for the diagnosis and treatment process.

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良性关节活动亢进和幼年纤维肌痛综合征合并症对小儿功能性胃肠疾病的影响。

目的:在儿科门诊患者中，肌肉骨骼疼痛的发生率相当高。良性关节活动过度(BJHS)和青少年纤维肌痛综合征(JFMS)是肌肉骨骼疼痛的非炎症性原因。在这些综合征中，疼痛通常伴有各种症状，如疲劳、睡眠困难、情绪障碍、认知功能障碍、头晕、头痛、腹痛、肠易激综合征和不宁腿综合征。功能性消化不良、功能性呕吐、功能性腹痛、功能性便秘和肠易激综合征统称为功能性胃肠(GI)疾病。我们的目的是评估BJHS和JFMS与功能性胃肠疾病的关系。方法:选取10-18岁儿童消化内科诊断为功能性胃肠道疾病的患者。儿科风湿病科对BJHS和JFMS的结果进行评估。焦虑、躯体化和抑郁量表由儿童精神病学家管理。自主神经功能障碍采用COMPASS 31评分。结果:功能性胃肠道疾病患儿JFMS和BJHS患病率分别为64%和32%。胸骨后胸痛、吞咽困难、早期饱腹感、恶心、呕吐和反流在JFMS中很常见(p = 0.007;P = 0.005;P = 0.018;P = 0.002, P = 0.013;P = 0.014)。胃肠道症状与BJHS无明显差异。体位不耐受106例(88.3%)，反射性晕厥99例(82.5%)。有焦虑症状103例(85.6%)，躯体化症状101例(84.2%)，抑郁症状102例(85%)。结论:功能性GI障碍、JFMS和BJHS是由情绪困扰影响的复杂的相互交织的疾病。因此，多学科的方法是必要的诊断和治疗过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medicine 医学-医学：内科

CiteScore

6.10

自引率

2.40%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916, Postgraduate Medicine was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.