Management of oral mucositis: a systematic review.

IF 1.1 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Minerva dental and oral science Pub Date : 2023-10-01 Epub Date: 2023-04-17 DOI:10.23736/S2724-6329.23.04695-8
Joey Danwiek, Rahmi Amtha, Indrayadi Gunardi
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引用次数: 1

Abstract

Introduction: Oral mucositis is one of the most common complications following chemotherapy and/or head and neck radiotherapy. Various treatments for oral mucositis have been proposed. However, there has still been no review of the most frequent and most effective type of therapy to treat oral mucositis. This systematic review aims to determine the most frequent and effective types of therapy to treat and reduce the severity of oral mucositis.

Evidence acquisition: The literature search was carried out using PRISMA guidelines. Publications included from 2010 to June 2021 with a clinical trial, prospective, and retrospective observational research design. The following databases were used: PubMed, Cochrane Library, and Wiley Online Library. The search was for limited articles published in English, which were screened and analyzed by three authors. The risk of bias of each study was also assessed by three authors simultaneously, using different types of instruments depending on its study design.

Evidence synthesis: Forty-seven of 1274 journals were included. From 3577 subjects, oral mucositis was more common in males than females (2.12: 1), with a mean age of 56.39 (18-90 years). The most commonly used types of therapy are low-level laser therapy (396 subjects) and lysozyme-based compounds (314 subjects). Meanwhile, the most effective type of therapy is low-level laser therapy.

Conclusions: Low-level laser therapy is the most commonly used oral mucositis therapy and is also the most effective in reducing the degree of oral mucositis and associated pain.

口腔粘膜炎的治疗:一项系统综述。
引言:口腔粘膜炎是化疗和/或头颈部放疗后最常见的并发症之一。已经提出了多种治疗口腔粘膜炎的方法。然而,目前还没有关于治疗口腔粘膜炎最常见、最有效的治疗方法的综述。本系统综述旨在确定治疗和减轻口腔粘膜炎严重程度的最常见和最有效的治疗类型。证据获取:使用PRISMA指南进行文献检索。出版物包括2010年至2021年6月的临床试验、前瞻性和回顾性观察性研究设计。使用了以下数据库:PubMed、Cochrane Library和Wiley Online Library。搜索的是以英语发表的有限文章,由三位作者进行筛选和分析。每项研究的偏倚风险也由三位作者同时评估,根据研究设计使用不同类型的仪器。证据综合:1274种期刊中有47种被收录。在3577名受试者中,口腔粘膜炎在男性中比女性更常见(2.12:1),平均年龄为56.39岁(18-90岁)。最常用的治疗类型是低水平激光治疗(396名受试者)和基于溶菌酶的化合物(314名受试人)。同时,最有效的治疗方式是低水平的激光治疗。结论:低水平激光治疗是最常用的口腔粘膜炎治疗方法,也是降低口腔粘膜炎程度和相关疼痛的最有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Minerva dental and oral science
Minerva dental and oral science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
2.50
自引率
5.00%
发文量
61
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