Luteal phase support in assisted reproductive technology centers: Italian survey.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Minerva obstetrics and gynecology Pub Date : 2024-04-01 Epub Date: 2023-04-14 DOI:10.23736/S2724-606X.22.05219-8
Antonio LA Marca, Paola Anserini, Andrea Borini, Giuseppe D'Amato, Ermanno Greco, Claudia Livi, Enrico Papaleo, Rocco Rago
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引用次数: 0

Abstract

Background: In assisted reproductive cycles (ART), the fine balance of controlling corpus luteum function is severely disrupted. To challenge this iatrogenic deficiency, clinicians aim to provide exogenous support. Several reviews have investigated progesterone route of administration, dosage and timing.

Methods: A survey about luteal phase support (LPS) after ovarian stimulation was conducted among doctors in charge in Italian II-III level ART centers.

Results: With regards to the general approach to LPS, 87.9% doctors declare to diversify the approach; the reasons for diversifying (69.7%) were based on the type of cycle. For all the most important administration routes (vaginal, intramuscular, subcutaneous) it appears that in frozen cycles there is a shift towards higher dosages. The 90.9% of the centers use vaginal progesterone, and when a combined approach is required, in 72.7% of cases vaginal administration is combined with injective route of administration. When Italian doctors were asked about the beginning and duration of LPS, 96% of the centers start the day of the pickup or the day after, while 80% of the centers continue LPS until week 8-12. The rate of participation of the centers confirms the low perceived importance of LPS among Italian ART centers, while may be considered quite surprising the relatively higher percentage of centers that measures P level. Tailorization to women's needs is the new objective of LPS: self-administration, good tolerability are the main aspects for Italian centers.

Conclusions: In conclusion, results of Italian survey are consistent to results of main international surveys about LPS.

辅助生殖技术中心的黄体期支持:意大利调查
背景:在辅助生殖周期(ART)中,控制黄体功能的微妙平衡被严重破坏。为了应对这种先天不足,临床医生希望提供外源性支持。一些综述对黄体酮的给药途径、剂量和时间进行了研究:方法:对意大利II-III级ART中心的主管医生进行了一项关于卵巢刺激后黄体期支持(LPS)的调查:结果:关于黄体期支持的一般方法,87.9%的医生宣布采用多样化方法;多样化的原因(69.7%)基于周期类型。就所有最重要的给药途径(阴道给药、肌肉注射、皮下注射)而言,在冷冻周期中似乎都在向大剂量转变。90.9% 的中心使用阴道黄体酮,在需要联合用药时,72.7% 的情况下阴道给药与注射给药相结合。当意大利医生被问及 LPS 的开始时间和持续时间时,96% 的中心在取卵当天或次日开始,而 80% 的中心将 LPS 持续到第 8-12 周。各中心的参与率证实,意大利抗逆转录病毒疗法中心认为 LPS 的重要性较低,而测量 P 水平的中心比例相对较高,这可能令人感到非常惊讶。根据妇女的需求量身定制是 LPS 的新目标:自我管理、良好的耐受性是意大利中心的主要方面:总之,意大利的调查结果与有关 LPS 的主要国际调查结果是一致的。
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来源期刊
Minerva obstetrics and gynecology
Minerva obstetrics and gynecology OBSTETRICS & GYNECOLOGY-
CiteScore
2.90
自引率
11.10%
发文量
191
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