Correlation between magnesium sulphate exposure in utero and serum calcium and alkaline phosphatase levels in preterm infants

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Magnesium research Pub Date : 2022-10-01 DOI:10.1684/mrh.2023.0509

Aoki Kuraaki, Matsu-Uchi Shoko, Akaba Kazuhiro

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引用次数: 0

Abstract

Introduction: Magnesium sulphate (MgSO4) is administered to pregnant women at risk of preterm labour and eclampsia. Since prolonged exposure to antenatal MgSO4 is considered to be a risk factor for infant skeletal demineralization, we evaluated infants exposed to antenatal MgSO4 for bone and mineral metabolism using their umbilical cord blood.

Materials and methods: The study population comprised 137 preterm infants. Forty-three infants were exposed (exposure group) and 94 infants were not exposed (control group) to antenatal MgSO4. Blood samples from the umbilical cords and infants were analysed with respect to mineral metabolism, intact parathyroid hormone (iPTH) level, and alkaline phosphatase (ALP) level. Correlation between the level of these parameters and the duration and dosage of MgSO4 was also examined.

Results: Preterm infants in the exposure group were antenatally exposed to MgSO4 for a median (IQR) period of 14 (5-34) days and a dosage of 447 (138-1118) g. Serum calcium levels were lower (8.8 vs 9.4 mg/dL, p<0.001) and ALP levels were higher (312 vs 196 U/L, p<0.001) in the exposure group. Serum calcium levels did not correlate with MgSO4 administration dosage and therapy duration, however, ALP levels correlated with the duration and total dosage of MgSO4 (Spearman's rank correlation r [95% confidence interval]: 0.55 [0.30-0.73], p <0.001 and 0.63 [0.40-0.78], p <0.001, respectively).

Conclusion: Prolonged periods and higher doses of antenatal MgSO4 exposure can cause in utero abnormal bone metabolism in preterm infants.

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子宫内硫酸镁暴露与早产儿血清钙和碱性磷酸酶水平的相关性

简介:硫酸镁(MgSO4)适用于有早产和子痫风险的孕妇。由于长期暴露于产前MgSO4被认为是婴儿骨骼脱矿的一个危险因素，我们使用脐带血评估了暴露于产前MgSO4的婴儿的骨骼和矿物质代谢。材料和方法:研究人群包括137名早产儿。43名婴儿暴露于MgSO4(暴露组)，94名婴儿未暴露(对照组)。对脐带和婴儿的血液样本进行了矿物质代谢、完整甲状旁腺激素(iPTH)水平和碱性磷酸酶(ALP)水平的分析。研究了这些参数的水平与MgSO4的持续时间和用量之间的相关性。结果:暴露组早产儿在产前暴露于MgSO4的中位(IQR)期为14(5-34)天，剂量为447 (138-1118)g，血清钙水平较低(8.8 vs 9.4 mg/dL)。结论:长时间和高剂量的产前MgSO4暴露可导致早产儿子宫内骨代谢异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.