Transanal drainage tube for the prevention of anastomotic leakage in anterior resection for rectal cancer: a systematic review and meta-analysis.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2023-04-01 DOI:10.1080/14737140.2023.2179991

Wei Wang, Jianping Zhang, Jumei Cai, Xinmin Zhao, Fazhi Wang

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引用次数: 0

Abstract

Objective: To evaluate the ability of the transanal drainage tube (TDT) to prevent anastomotic leakage (AL) and provide clinicians with the latest evidence in this area.

Materials and methods: We search for relevant studies according to a search strategy. Data extracted from the study were analyzed using RevMan 5.4 software.

Results: Fourteen eligible studies were included in our meta-analysis. The results of this meta-analysis suggest that patients with TDT placement have a lower incidence of AL than those without TDT placement (6% vs. 9.1%) (RR = 0.58, 95% CI: 0.46, 0.73, P < 0.00001). However, pooled results from RCTs suggest that TDT does not appear to reduce the incidence of AL in patients (6.4% vs. 8%) (RR = 0.79, 95% CI 0.52, 1.18, P = 0.24). In addition, the results of the meta-analysis suggest that TDT appears to reduce patient reoperation rates (2.6% vs. 5.8%) (RR = 0.38, 95% CI 0.27, 0.54, P < 0.00001).

Conclusions: The results of the RCTs suggest that TDT placement does not reduce the AL rate in patients, however, it is undeniable that the placement of TDT does provide patients with some clinical benefits (such as reduced reoperation rates).

查看原文本刊更多论文

经肛门引流管预防直肠癌前切除术吻合口漏:系统综述和荟萃分析。

目的:评价经肛门引流管(TDT)预防吻合口漏(AL)的能力，为临床医生提供这方面的最新证据。材料与方法:根据检索策略检索相关研究。采用RevMan 5.4软件对研究数据进行分析。结果:我们的meta分析纳入了14项符合条件的研究。本荟萃分析结果显示，植入TDT的患者AL发生率低于未植入TDT的患者(6% vs. 9.1%) (RR = 0.58, 95% CI: 0.46, 0.73, P = 0.24)。此外，meta分析的结果表明，TDT似乎降低了患者的再手术率(2.6% vs. 5.8%) (RR = 0.38, 95% CI 0.27, 0.54, P)。结论:rct的结果表明，TDT的放置并没有降低患者的AL率，但不可否认的是，TDT的放置确实为患者提供了一些临床益处(如降低再手术率)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.