Brain network study of attentional cognitive impairment in children with bronchial asthma

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2023-01-12 DOI:10.1002/jdn.10250

Lin Zhu, Jing Zhao, Yuya Yang, Qiuling Shangguan, Yi Chen, Ye He, Jianfeng Wu, Congyin Qin, Jianxin Xiong, Kaihua Jiang

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引用次数: 2

Abstract

Bronchial asthma often causes cognitive impairment, especially attentional deficit, which has a serious impact on children's learning. This study aims to provide objective indicators for the evaluation of attention in asthma children. Thirty-one asthmatic and typically developing children (TDC) were tested by resting-state functional magnetic resonance imaging (rs-fMRI). Brain network-based methods of degree centricity and voxel-mirrored homotopic connectivity (VMHC) methods were used in the study. Compared with the TDC group, asthmatic children had lower DC values in the right superior frontal gyrus (after FDR correction, P < 0.05). Meanwhile, VMHC values of bilateral superior frontal gyrus and bilateral superior parietal lobule in asthmatic children were lower than those in TDC group (after FDR correction, P < 0.05). There was significant correlation between the correct percentage of CPT and DC value in right superior frontal gyrus, VMHC value in right superior frontal gyrus, and right superior parietal lobule. In this study, impaired superior frontal gyrus and parietal lobe function are associated with attentional deficit in asthmatic children, and these brain regions are key brain regions in attention-related networks.

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支气管哮喘患儿注意认知障碍的脑网络研究

支气管哮喘常引起认知障碍，尤其是注意力缺陷，严重影响儿童的学习。本研究旨在为哮喘患儿的注意力评价提供客观指标。采用静息状态功能磁共振成像(rs-fMRI)对31例哮喘和典型发育儿童(TDC)进行检测。研究采用了基于脑网络的度中心性方法和体素镜像同伦连通性(VMHC)方法。与TDC组相比，哮喘患儿右侧额上回DC值较低(FDR校正后，P < 0.05)。哮喘患儿双侧额上回和双侧顶叶上小叶VMHC值低于TDC组(FDR校正后，P < 0.05)。右额上回的CPT正确率与DC值、右额上回的VMHC值、右顶叶上小叶的CPT正确率有显著相关。本研究发现，哮喘儿童的上额回和顶叶功能受损与注意力缺陷有关，这些脑区是注意力相关网络的关键脑区。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.