{"title":"Identification of Genetic Risk Factors for Monogenic and Complex Canine Diseases.","authors":"Tosso Leeb, Danika Bannasch, Jeffrey J Schoenebeck","doi":"10.1146/annurev-animal-050622-055534","DOIUrl":null,"url":null,"abstract":"<p><p>Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The identification of disease-causing variants in dogs with monogenic diseases may become a widely employed diagnostic approach in clinical veterinary medicine in the not-too-distant future. Diseases with complex modes of inheritance continue to pose challenges to researchers but have also become much more tangible than in the past. In addition to strategies for identifying genetic risk factors, we provide some thoughts on the interpretation of sequence variants that are largely inspired by developments in human clinical genetics.</p>","PeriodicalId":48953,"journal":{"name":"Annual Review of Animal Biosciences","volume":"11 ","pages":"183-205"},"PeriodicalIF":8.7000,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Animal Biosciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1146/annurev-animal-050622-055534","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 1
Abstract
Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The identification of disease-causing variants in dogs with monogenic diseases may become a widely employed diagnostic approach in clinical veterinary medicine in the not-too-distant future. Diseases with complex modes of inheritance continue to pose challenges to researchers but have also become much more tangible than in the past. In addition to strategies for identifying genetic risk factors, we provide some thoughts on the interpretation of sequence variants that are largely inspired by developments in human clinical genetics.
期刊介绍：
The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.
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