Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy.

IF 1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Anales Del Sistema Sanitario De Navarra Pub Date : 2021-08-20 DOI:10.23938/ASSN.0947

C Pujol, N Varo Cenarruzabeitia, M Rodríguez Mañero, J Barba, S Castaño Rodríguez, A Macías Gallego, M J Torres, I García Bolao

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引用次数: 0

Abstract

Background: The aim of this paper is to analyze the role of the biomarkers Interleukin 6, Tumoral Necrosis Factor a, sCD40L, high sensitive Troponin T, high sensitive C-Reactive Protein and Galectin-3 in predicting super response (SR) to Cardiac Resynchronization Therapy (CRT), as they have not been studied in this field before.

Methods: Clinical, electrocardiographic and echocardiographic data was obtained preimplant and after one year. SR was defined as reduction in LVESV = 30% at one year follow-up. Blood samples were extracted preimplant. Multivariate logistic regression and ROC curves were performed.

Results: 50 patients were included, 23 (46%) were SR. Characteristics related to SR were: female (35 vs. 11%, p?=?0.04), suffering from less ischemic cardiomyopathy (13 vs. 63%, p?

Conclusions: sCD40L correlates significantly with SR to CRT. QRS width, absence of mitral regurgitation and lateral medial position of the lead are independent predictors of SR in this cohort.

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sCD40L在预测心脏再同步化治疗超反应中的作用。

背景:本文的目的是分析生物标志物白介素6、肿瘤坏死因子a、sCD40L、高敏肌钙蛋白T、高敏c反应蛋白和半乳糖凝集素-3在预测心脏再同步化治疗(CRT)超反应(SR)中的作用，因为这些标志物在该领域尚未被研究。方法:术前和术后1年的临床、心电图和超声心动图资料。SR定义为1年随访时LVESV降低= 30%。植入前提取血液样本。进行多因素logistic回归和ROC曲线分析。结果:纳入50例患者，23例(46%)为SR。SR相关特征为:女性(35例vs. 11%， p = 0.04)，缺血性心肌病较少(13例vs. 63%， p = 0.04)。结论:sCD40L与SR与CRT有显著相关性。QRS宽度、二尖瓣不反流和导联外侧内侧位置是该队列中SR的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anales Del Sistema Sanitario De Navarra 医学-公共卫生、环境卫生与职业卫生

CiteScore

1.30

自引率

30.00%

发文量

审稿时长

>12 weeks

期刊介绍： La revista Anales del Sistema Sanitario de Navarra es una revista de contenido médico sanitario de carácter generalista. En ella tienen cabida artículos referidos a temas de salud/enfermedad en general, salud pública, administración y gestión sanitaria y Atención Primaria de salud.