[Pembrolizumab-associated autoimmune encephalitis in an elderly patient with advanced non-small cell lung cancer. A clinical case].

IF 1 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
A Pozo Vico, N Gonzales Montejo, I Pagola Lorz, A Castillo Andueza, L Y Ortega Molina, F J Alonso Renedo
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引用次数: 1

Abstract

Therapeutic objectives for the geriatric patient are improvement of quality of life and functional capacity rather than a mere increase in survival. In neoplastic disease, the decision to initiate administration of curative therapies, especially immunotherapy, should be taken only after any potential risks have been taken into account. Geriatric patients are more susceptible to developing more serious adverse reactions than the younger population. We report the case of an octogenarian patient with non-small cell lung cancer who developed neurologic toxicity following pembroli-zumab therapy. We carry out a differential diagnosis of encephalitis and provide a literature review of pembrolizumab-associated auto-immune encephalitis cases in order to improve our knowledge of this unusual toxicity. An interdisciplinary approach and comprehensive geriatric assessment are essential components to prevent functional decline in the elderly.

老年晚期非小细胞肺癌患者的pembrolizumab相关性自身免疫性脑炎一个临床病例]。
老年患者的治疗目标是改善生活质量和功能能力,而不仅仅是增加生存时间。在肿瘤疾病中,只有在考虑到任何潜在风险后,才应决定开始治疗性治疗,特别是免疫治疗。老年患者比年轻人群更容易发生更严重的不良反应。我们报告一例八十多岁的非小细胞肺癌患者在接受pembroli-zumab治疗后出现神经毒性。我们对脑炎进行鉴别诊断,并对派姆单抗相关的自身免疫性脑炎病例进行文献综述,以提高我们对这种不寻常毒性的认识。跨学科的方法和全面的老年评估是预防老年人功能衰退的重要组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anales Del Sistema Sanitario De Navarra
Anales Del Sistema Sanitario De Navarra 医学-公共卫生、环境卫生与职业卫生
CiteScore
1.30
自引率
30.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: La revista Anales del Sistema Sanitario de Navarra es una revista de contenido médico sanitario de carácter generalista. En ella tienen cabida artículos referidos a temas de salud/enfermedad en general, salud pública, administración y gestión sanitaria y Atención Primaria de salud.
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