In vitro studies of the renin-angiotensin system in human adipose tissue/adipocytes and possible relationship to SARS-CoV-2: a scoping review.

IF 3.5 4区生物学 Q2 ENDOCRINOLOGY & METABOLISM

Adipocyte Pub Date : 2023-12-01 DOI:10.1080/21623945.2023.2194034

Ryan Ting, Heidi Dutton, Alexander Sorisky

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Abstract

The renin-angiotensin system (RAS) operates within adipose tissue. Obesity-related changes can affect adipose RAS, predisposing to hypertension, type 2 diabetes, and possibly severe COVID-19. We evaluated the in vitro research on human adipose RAS and identified gaps in the literature. Medline (Ovid), Embase (Ovid), Web of Science, Scopus, and 1findr were searched to identify relevant studies. Fifty primary studies met our inclusion criteria for analysis. Expression of RAS components (n = 14), role in differentiation (n = 14), association with inflammation (n = 15) or blood pressure (n = 7) were investigated. We found (1) obesity-related changes in RAS were frequently studied (30%); (2) an upswing of articles investigating adipose ACE-2 expression since the COVID-19 pandemic; (3) a paucity of papers on AT2R and Ang (1-7)/MasR which counterbalance Ang II/ART1; (4) weight loss lowered adipose ACE-2 mRNA expression; and (5) angiotensin receptor blockers (ARBs) reduced deleterious effects of angiotensin II. Overall, these studies link Ang II/ATR1 signalling to impaired adipogenesis and a pro-inflammatory dysfunctional adipose tissue, with ATR1 blockade limiting these responses. ACE-2 may mitigate Ang II effects by converting it to Ang(1-7) which binds MasR. More work is needed to understand adipose RAS in various pathologic states such as obesity and COVID-19 infection.T.

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人脂肪组织/脂肪细胞肾素-血管紧张素系统的体外研究及其与SARS-CoV-2的可能关系:范围综述

肾素-血管紧张素系统（RAS）在脂肪组织中起作用。肥胖相关的变化会影响脂肪RAS，易患高血压、2型糖尿病，并可能导致严重的新冠肺炎。我们评估了人类脂肪RAS的体外研究，并确定了文献中的空白。检索Medline（Ovid）、Embase（Ovid）、Web of Science、Scopus和1findr以确定相关研究。50项初级研究符合我们的纳入标准进行分析。RAS成分的表达（n = 14），在分化中的作用（n = 14），与炎症有关（n = 15）或血压（n = 7）进行了调查。我们发现（1）RAS中与肥胖相关的变化经常被研究（30%）；（2）自新冠肺炎大流行以来，研究脂肪ACE-2表达的文章增多；（3）关于AT2R和Ang（1-7）/MasR平衡Ang II/ART1的论文很少；（4）体重减轻降低了脂肪ACE-2 mRNA的表达；和（5）血管紧张素受体阻滞剂（ARBs）减少了血管紧张素II的有害作用。总之，这些研究将Ang II/ATR1信号传导与受损的脂肪生成和促炎性功能失调的脂肪组织联系起来，ATR1阻断限制了这些反应。ACE-2可以通过将其转化为结合MasR的Ang（1-7）来减轻Ang II的作用。需要更多的工作来了解肥胖和新冠肺炎感染等各种病理状态下的脂肪RAS。T

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来源期刊

Adipocyte Medicine-Histology

CiteScore

6.50

自引率

3.00%

发文量

审稿时长

32 weeks

期刊介绍： Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.