Reduced eye optical quality contributes to worse chromatic thresholds in aging.

IF 2.6 3区医学 Q2 BEHAVIORAL SCIENCES

Frontiers in Integrative Neuroscience Pub Date : 2023-01-01 DOI:10.3389/fnint.2023.1129315

Marcelo Fernandes Costa, Livia Soledade Rego, Leonardo Dutra Henriques, Carlo Martins Gaddi, Givago Silva Souza

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Abstract

Purpose: Aging causes substantial changes in the intraocular lens, which leads to a reduction in chromatic perception. We aimed to measure the ocular light dispersion component in relation to the reduction in color vision by aging.

Methods: Intraocular straylight was quantified psychophysically by C-Quant for light dispersion [Log(s)], reliability of the results (ESD), and psychometric sampling quality (Q). The Cambridge Color Test Trivector protocol measured the chromaticity thresholds for protan, deutan, and tritan color confusion axis in CIE 1976 u' v' units. We tested 224 subjects aged 24-68 years (106 men) with normal best-corrected visual acuity and without clinical evidence of cataracts.

Results: A significant positive correlation was found between ocular dispersion of light and chromaticity thresholds for protan (r = 0.42; p < 0.001), deutan (r = 0.49; p < 0.001) and tritan (r = 0.51; p < 0.0001) color confusion axes with a moderate effect size (η² = 0.39). However, a weak contribution of the logarithm of the straylight in predicting the chromaticity threshold for protan (b = 0.15; p = 0.025), deutan (b = 0.27; p = 0.001) and tritan (b = 0.21; p = 0.001) color confusion axes was verified in the regression coefficients. The other two measurement quality parameters estimated in the C-Quant were not correlated with chromaticity thresholds, suggesting that there are no problems with the quality of the measurement performed.

Conclusion: An increase in ocular light dispersion that occurs physiologically with aging negatively impacts the chromaticity threshold in a similar manner across all three color confusion axes. The weak regression effects suggest that neural rather than optical processes were more related to the reduction in chromaticity in aging.

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眼睛光学质量的降低会导致老化的色阈值变差。

目的:衰老导致人工晶状体发生实质性变化，导致色觉下降。我们的目的是测量眼部光色散成分与色觉减少有关的老化。方法:采用C-Quant对眼内散光进行心理物理定量，测量光色散[Log(s)]、结果可靠性(ESD)和心理测量采样质量(Q)。剑桥颜色测试三向量方案测量了色度阈值在CIE 1976 u' v'单位中的色度混淆轴(protean, deutan, tritan)。我们测试了224名24-68岁的受试者(106名男性)，他们的最佳矫正视力正常，没有白内障的临床证据。结果:眼光色散与蛋白色度阈值呈正相关(r = 0.42;P < 0.001)，德国(r = 0.49;P < 0.001)和tritan (r = 0.51;P < 0.0001)色混淆轴具有中等效应大小(η2 = 0.39)。然而，散光的对数在预测蛋白质的色度阈值方面的贡献很小(b = 0.15;P = 0.025)， deutan (b = 0.27;P = 0.001)和tritan (b = 0.21;P = 0.001)，颜色混淆轴在回归系数中得到验证。C-Quant中估计的其他两个测量质量参数与色度阈值不相关，这表明执行的测量质量没有问题。结论:随着年龄的增长，眼光色散的增加对色度阈值产生了类似的负面影响。弱回归效应表明，在衰老过程中，神经过程比光学过程与色度降低的关系更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience

CiteScore

4.60

自引率

2.90%

发文量

148

审稿时长

14 weeks

期刊介绍： Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.