A Pilot Study on COVID-19 Positive Subjects: An Excerpt of Post-Infection-Pro-Diabetic Disposition & Related Consequences in Correlation to Hepato-Pancreatic Bio-Markers, Pro-Inflammatory Cytokines and Other Risk Factors.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Indian Journal of Clinical Biochemistry Pub Date : 2023-04-01 DOI:10.1007/s12291-022-01054-8

Sushil Kumar, Neha Rai, Akash Bansal, Amit Mittal, Nimai Chand Chandra

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Abstract

COVID-19, a global pandemic that led to increased morbidity and mortality worldwide since its outcome at the end of the year 2019. A newly discovered variant of severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) was the arbitrator for spreading the syndrome by droplet transmission causing multi-organ failure in many occasions. A post-infection-pro-diabetic disposition was found evident in this study with the persistence of hepato-pancreatic aberrations in respect of reference range of tissue specific bio-markers in hospital admitted COVID-19 cases. The results of this study show that hyperglycemia is a risk factor in precipitating disease oriented complications to the patients with COVID-19 disease. A post-infection follow- up on glycemic-index and related complexities is a vital need to the COVID-19 infected convalescent subjects. Implementation of guidelines on social measure and awareness of anti-viral interventions may be the only way to prevent COVID-19 transmission.

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COVID-19阳性受试者的初步研究:感染后糖尿病倾向及其与肝胰腺生物标志物、促炎细胞因子和其他危险因素的相关后果摘录

2019冠状病毒病是一场全球大流行，自2019年底爆发以来，导致全球发病率和死亡率上升。新发现的严重急性呼吸窘迫综合征冠状病毒-2 (SARS-CoV-2)变体是该综合征通过飞沫传播导致多器官功能衰竭的仲裁者。本研究发现，入院的COVID-19病例感染后糖尿病倾向明显，在组织特异性生物标志物的参考范围内持续存在肝胰腺畸变。本研究结果表明，高血糖是新冠肺炎患者发生疾病导向并发症的危险因素。对COVID-19感染的恢复期受试者进行感染后血糖指数及相关复杂性随访是至关重要的。实施关于社会措施和认识抗病毒干预措施的指导方针可能是预防COVID-19传播的唯一途径。

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来源期刊

Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.50

自引率

4.80%

发文量

期刊介绍： The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.