Insight into epigenetics and human diseases.

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI:10.1016/bs.pmbts.2023.01.007

Ankita Saini, Adya Varshney, Ashok Saini, Indra Mani

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Abstract

The most eminent research of the 21st century whirls around the epigenetic and the variability of DNA sequences in humans. The reciprocity between the epigenetic changes and the exogenous factors drives an influence on the inheritance biology and gene expression both inter-generationally and trans-generationally. Chromatin level modifications like DNA methylation, histone modifications or changes in transcripts functions either at transcription level or translational level pave the way for certain diseases or cancer in humans. The ability of epigenetics to explain the processes of various diseases has been demonstrated by recent epigenetic studies. Multidisciplinary therapeutic strategies were developed in order to analyse how epigenetic elements interact with different disease pathways. In this chapter we summarize how an organism may be predisposed to certain diseases by exposure to environmental variables such as chemicals, medications, stress, or infections during particular, vulnerable phases of life, and the epigenetic component may influence some of the diseases in humans.

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洞察表观遗传学和人类疾病。

21世纪最杰出的研究围绕着人类DNA序列的表观遗传学和可变性展开。表观遗传变化与外源因素的相互作用对遗传生物学和基因表达产生代际和跨代影响。染色质水平的改变，如DNA甲基化，组蛋白修饰或转录本功能的改变，无论是在转录水平还是翻译水平，都为人类的某些疾病或癌症铺平了道路。最近的表观遗传学研究证明了表观遗传学解释各种疾病过程的能力。为了分析表观遗传因素如何与不同的疾病途径相互作用，开发了多学科治疗策略。在本章中，我们总结了在生命的特定脆弱阶段，生物体如何暴露于环境变量，如化学物质、药物、压力或感染，从而易患某些疾病，以及表观遗传成分如何影响人类的某些疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.