Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY

Annual review of genetics Pub Date : 2022-11-30 DOI:10.1146/annurev-genet-072920-125226

Jennifer A Urban, Rajesh Ranjan, Xin Chen

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引用次数: 1

Abstract

The discovery of biased histone inheritance in asymmetrically dividing Drosophila melanogaster male germline stem cells demonstrates one means to produce two distinct daughter cells with identical genetic material. This inspired further studies in different systems, which revealed that this phenomenon may be a widespread mechanism to introduce cellular diversity. While the extent of asymmetric histone inheritance could vary among systems, this phenomenon is proposed to occur in three steps: first, establishment of histone asymmetry between sister chromatids during DNA replication; second, recognition of sister chromatids carrying asymmetric histone information during mitosis; and third, execution of this asymmetry in the resulting daughter cells. By compiling the current knowledge from diverse eukaryotic systems, this review comprehensively details and compares known chromatin factors, mitotic machinery components, and cell cycle regulators that may contribute to each of these three steps. Also discussed are potential mechanisms that introduce and regulate variable histone inheritance modes and how these different modes may contribute to cell fate decisions in multicellular organisms.

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不对称组蛋白遗传:建立、识别和执行。

在不对称分裂的黑腹果蝇雄性生殖系干细胞中发现了偏向的组蛋白遗传，证明了一种产生具有相同遗传物质的两个不同子细胞的方法。这启发了在不同系统中的进一步研究，揭示了这种现象可能是引入细胞多样性的广泛机制。虽然组蛋白不对称遗传的程度在不同的系统中可能有所不同，但这种现象可能发生在三个步骤中:首先，在DNA复制过程中姐妹染色单体之间建立组蛋白不对称;其次，在有丝分裂过程中识别携带不对称组蛋白信息的姐妹染色单体;第三，在产生的子细胞中执行这种不对称。通过汇编来自不同真核系统的现有知识，本文全面详细介绍并比较了可能对这三个步骤有贡献的已知染色质因子、有丝分裂机制成分和细胞周期调节因子。还讨论了引入和调节可变组蛋白遗传模式的潜在机制，以及这些不同模式如何影响多细胞生物的细胞命运决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.