Current Approach to Renal Transplantation Candidates and Potential Donors with Viral Hepatitis.

Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) Pub Date : 2023-03-01 DOI:10.2478/prilozi-2023-0015

Berfu Korucu, Sena Ulu, Ozkan Gungor

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Abstract

Renal transplantation is the most beneficial treatment in patients with chronic kidney disease (CKD), increasing life expectancy and improving quality of life. A better understanding of organ and tissue functions, the development of surgical techniques, and new and effective immunosuppressive and antimicrobial drugs increase the success of transplantation. However, the number of renal transplantations from living and cadaveric donors is not at the desired frequency. Among the leading causes of the restrictions for transplantation are both the recipients' and donors' chronic diseases. While hepatitis B and C infections are a significant problem affecting the number and success of renal transplantations, the innovation of hepatitis C virus treatments has improved outcomes. Thus, the recipient and donor hepatitis B and C virus infections are no longer considered as relative contraindications for renal transplantation. This review discusses the management of patients and donors with hepatitis B and hepatitis C in renal transplantation.

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病毒性肝炎患者肾移植候选人和潜在供体的当前方法。

肾移植是慢性肾脏疾病(CKD)患者最有益的治疗方法，可以延长预期寿命，提高生活质量。对器官和组织功能的更好理解、手术技术的发展以及新的有效的免疫抑制和抗菌药物增加了移植的成功率。然而，活体和尸体供体肾移植的数量并没有达到预期的频率。限制移植的主要原因是受者和供者的慢性疾病。虽然乙型和丙型肝炎感染是影响肾移植数量和成功的一个重要问题，但丙型肝炎病毒治疗的创新改善了结果。因此，受体和供体乙型和丙型肝炎病毒感染不再被认为是肾移植的相对禁忌症。本文综述了乙型肝炎和丙型肝炎患者和供体在肾移植中的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

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