Canna starch improves immune functions and the intestinal environment in mice.

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI:10.12938/bmfh.2022-068

Mamoru Tanaka, Ayaka Koida, Akira Miyazaki, Kazushi Tabata, Yuichiro Takei, Yoshihumi Tanimoto, Mami Kawamura, Masafumi Tsuzuki, Haruka Takahashi, Tetsu Yano, Hiroyuki Watanabe

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Abstract

The present study was conducted to elucidate the dietary effects of canna starch on the immune functions and intestinal luminal environment in mice. The amylose and resistant starch characteristics were determined for six types of starch, including edible canna. Canna starch was found to be higher in amylose and resistant starch compared with the other starches. BALB/c mice were fed 3.16% (low-canna group) and 6.32% (high-canna group) canna starch for 2 weeks, and then intestinal parameters were measured. Fecal IgA and mucin levels were markedly elevated by canna starch intake. IgA levels in serum and spleen lymphocytes were elevated by canna starch intake in the high-canna group, but not in the low-canna group. When the mice were fed canna starch, the cecum weight increased, and the pH in the cecum decreased. The high-canna group had significantly increased levels of Clostridium subcluster XIVa lactic acid, acetic acid, and n-butyric acid in the cecum compared with the control group. These results suggested that canna starch supplementation changed the intestinal microbiota and enhanced the intestinal immune and barrier functions and cecal organic acids in mice.

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美人蕉淀粉改善小鼠免疫功能和肠道环境。

本研究旨在探讨美人蕉淀粉对小鼠免疫功能和肠道环境的影响。测定了包括美人蕉在内的6种淀粉的直链淀粉和抗性淀粉的特性。与其他淀粉相比，美人蕉淀粉的直链淀粉和抗性淀粉含量较高。BALB/c小鼠分别饲喂3.16%(低美人蕉组)和6.32%(高美人蕉组)美人蕉淀粉2周，测定肠道参数。摄入美人蕉淀粉后，粪便IgA和粘蛋白水平显著升高。高美人蕉淀粉摄取量组血清和脾脏淋巴细胞IgA水平升高，低美人蕉摄取量组无升高。饲喂美人蕉淀粉后，小鼠盲肠重量增加，盲肠pH值降低。与对照组相比，高剂量美人蕉组的盲肠中Clostridium亚群XIVa乳酸、乙酸和正丁酸水平显著增加。上述结果提示，美人蕉淀粉的添加改变了小鼠肠道菌群，增强了肠道免疫和屏障功能以及盲肠有机酸。

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.