Prevalence of fosA3 Gene in Fosfomycin-Resistant Proteus mirabilis in the Autonomous Community of Madrid (Spain) and Characterization of Two Positive Strains.

IF 2.3 4区医学 Q3 INFECTIOUS DISEASES

Microbial drug resistance Pub Date : 2023-10-01 Epub Date: 2023-04-06 DOI:10.1089/mdr.2022.0269

Cristina Loras, María Pérez-Vázquez, Andrea González Prieto, Jesús Oteo-Iglesias, Juan-Ignacio Alós

引用次数: 1

Abstract

Plasmid-mediated resistance to fosfomycin has been seldom described in Proteus mirabilis. We report two strains harboring fosA3 gene. Whole-genome sequencing revealed a plasmid that encoded fosA3 gene flanked by two insertion sequence (IS)26 mobile elements. Both strains also produced the bla_CTX-M-65 gene that was located in the same plasmid. The sequence detected was IS1182-bla_CTX-M-65-orf1-orf2-IS26-IS26-fosA3-orf1-orf2-orf3-IS26. The importance of this transposon lies in its ability to spread in Enterobacterales, therefore, epidemiological surveillance should be carried out.

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西班牙马德里自治区耐磷霉素奇异变形杆菌中fosA3基因的患病率和两株阳性菌株的特征。

在奇异变形杆菌中很少描述质粒介导的对磷霉素的耐药性。我们报道了两株携带fosA3基因的菌株。全基因组测序显示一个质粒编码fosA3基因，两侧有两个插入序列（IS）26移动元件。两个菌株也产生了位于同一质粒中的blaCTX-M-65基因。检测到的序列为IS1182-laCTX-M-65-或f1-orf2-IS26-IS26-fosA3-orf1-orf2-orf3-IS26。这种转座子的重要性在于它在肠杆菌中传播的能力，因此，应该进行流行病学监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial drug resistance 医学-传染病学

CiteScore

6.00

自引率

3.80%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.