The relationship between connexin-43 expression and Ki67 in non-glial central nervous system tumors.

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

International Journal of Biological Markers Pub Date : 2023-03-01 DOI:10.1177/03936155221143138

Aleksandrs Krigers, Patrizia Moser, Helga Fritsch, Matthias Demetz, Johannes Kerschbaumer, Konstantin R Brawanski, Claudius Thomé, Christian F Freyschlag

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引用次数: 0

Abstract

Background: Advanced intercellular communication is a known oncogenic factor. In the central nervous system, Connexin-43 (Cx43) forms this junctional networking. Moreover, it correlates with the proliferation rate, and thus behavior, of gliomas. We assessed the expression of Cx43 and its relationship to Ki67 in other common central nervous system tumors.

Methods: The expression of Cx43 and Ki67 were assessed in formalin-fixed paraffin embedded samples of human brain metastases, meningiomas, and neurinomas using immunohistochemistry. Neurinomas and meningiomas were jointly evaluated due to similar non-malignant behavior.

Results: A total of 14 metastases of different extracerebral carcinomas, 6 meningiomas, and 10 neurinomas were evaluated. Five (36%) metastases and 5 (31%) meningiomas/neurinomas showed minor expression, whereas 6 (43%) metastases and 2 (13%) meningiomas/neurinomas showed no Cx43 expression at all. In 3 (21%) metastases and 9 (56%) meningiomas/neurinomas, moderate or strong expression of Cx43 was identified. The higher expression of Cx43 in meningiomas and neurinomas directly correlated with Ki67, r = 0.53 (P = 0.034). For metastases no significant correlation was found. Mitotic index in meningiomas/neurinomas correlated with Ki67 expression, r = 0.74 (P < 0.001), but did not show statistically significant correlation with Cx43 expression in these tumors.

Conclusions: The expression of Cx43 as a marker of cell-to-cell networking exposed a significant correlation with the Ki67-defined proliferation index in case of primary central nervous system neuroectodermal neoplasms. However, it does not seem to play a comparable role in metastases with extracerebral origin.

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非胶质中枢神经系统肿瘤中连接蛋白43表达与Ki67的关系。

背景:先进的细胞间通讯是一个已知的致癌因素。在中枢神经系统中，连接蛋白-43 (Cx43)形成这种连接网络。此外，它还与胶质瘤的增殖速率和行为有关。我们评估了其他常见中枢神经系统肿瘤中Cx43的表达及其与Ki67的关系。方法:应用免疫组织化学方法检测人脑转移瘤、脑膜瘤和神经鞘瘤经福尔马林固定石蜡包埋标本中Cx43和Ki67的表达。神经瘤和脑膜瘤由于相似的非恶性行为而被联合评估。结果:本组共14例脑外转移瘤，脑膜瘤6例，神经瘤10例。5例(36%)转移瘤和5例(31%)脑膜瘤/神经鞘瘤表达较少，而6例(43%)转移瘤和2例(13%)脑膜瘤/神经鞘瘤未表达Cx43。在3例(21%)转移瘤和9例(56%)脑膜瘤/神经瘤中发现中度或强烈表达Cx43。Cx43在脑膜瘤和神经鞘瘤中的高表达与Ki67直接相关，r = 0.53 (P = 0.034)。对于转移性肿瘤，没有发现明显的相关性。结论:在原发性中枢神经系统神经外胚层肿瘤中，作为细胞间网络标志物的Cx43的表达与Ki67定义的增殖指数有显著相关性。然而，它在脑外转移瘤中似乎没有类似的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Markers 医学-生物工程与应用微生物

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.