[Autologous fibrin glue for endoscopic skull base repair in patients with cerebrospinal fluid leakage].

Q4 Medicine

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2023-01-01 DOI:10.17116/neiro20238701149

E V Shelesko, V A Doronina, O I Sharipov, O K Kvan, N A Chernikova, Yu V Strunina, D N Zinkevich

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引用次数: 1

Abstract

The main stages of endoscopic skull base repair in patients with cerebrospinal fluid (CSF) leakage are identification of bone boundaries of the fistula and its closure by auto- and allografts. Fibrin glue can be used to fix plastic materials and additionally seal skull base defect.

Objective: To analyze efficacy and safety of Vivostat autologous fibrin glue for endoscopic skull base repair in patients with nasal CSF leakage and to compare postoperative outcomes after defect closure by Vivostat fibrin glue and allogeneic fibrin glue.

Material and methods: A retro- and prospective analysis included 56 patients with nasal CSF leakage who were treated at the Burdenko Neurosurgery Center between January 2021 and June 2022. Patients were divided into 2 groups: Vivostat fibrin glue (n=27, 48.2%) and allogeneic fibrin glue (n=29, 51.8%). Demographic and clinical perioperative data were analyzed.

Results: No early postoperative recurrence of CSF leakage was registered in both groups, whereas meningitis occurred in 2 cases in each group. Recurrent CSF leakage in delayed postoperative period occurred in 1 patient (3.4%) of the control group (p>0.05). Incidence of perioperative complications, subfebrile temperature in early postoperative period, surgery time and hospital-stay were similar.

Conclusion: Vivostat autologous fibrin glue is a safe and effective method for fixing the grafts in endoscopic skull base repair. The advantages of this approach are easy application, elimination of the risk of allergic, immunological and infectious complications, as well as acceleration of tissue regeneration.

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自体纤维蛋白胶在脑脊液漏患者颅底修复中的应用

脑脊液(CSF)漏患者的内镜颅底修复的主要阶段是确定瘘的骨边界，并通过自体和同种异体移植物关闭瘘。纤维蛋白胶可用于塑料材料的固定，也可用于颅底缺损的封闭。目的:分析Vivostat自体纤维蛋白胶用于鼻脑脊液漏鼻内镜颅底修复的疗效和安全性，并比较Vivostat纤维蛋白胶与异体纤维蛋白胶缝合缺损的术后效果。材料和方法:回顾性和前瞻性分析包括56例鼻脑脊液漏患者，这些患者于2021年1月至2022年6月在Burdenko神经外科中心接受治疗。患者分为两组:Vivostat纤维蛋白胶(n=27, 48.2%)和同种异体纤维蛋白胶(n=29, 51.8%)。分析人口学和临床围手术期资料。结果:两组术后早期均无脑脊液漏复发，两组均有2例脑膜炎发生。对照组术后迟发期复发脑脊液漏1例(3.4%)，差异有统计学意义(p>0.05)。围手术期并发症发生率、术后早期亚热体温、手术时间、住院时间相似。结论:Vivostat自体纤维蛋白胶是内镜下颅底修复中固定移植物安全有效的方法。这种方法的优点是易于应用，消除过敏、免疫和感染并发症的风险，以及加速组织再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Medicine-Neurology (clinical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Scientific and practical peer-reviewed journal. This publication covers the theoretical, practical and organizational problems of modern neurosurgery, the latest advances in the treatment of various diseases of the central and peripheral nervous system. Founded in 1937. English version of the journal translates from Russian version since #1/2013.