Cardiorespiratory coupling is associated with exercise capacity in athletes: A cross-sectional study

Abstract

Purpose

To determine the association between exercise capacity based on peak oxygen uptake (VO_2peak) and resting cardiorespiratory coupling (CRC) levels in athletes and non-athletes’ subjects.

Methods

A cross-sectional study was carried out in 42 apparently healthy male subjects, aged between 20 and 40 years old. The participants were allocated into athletes (n = 21) and non-athletes (n = 21) groups. Resting electrocardiogram and respiratory movement (RESP) were simultaneously acquired during 15 min in supine position and quiet breathing. The beat-to-beat heart period (HP) and RESP series were determined from the recorded signals. Traditional analysis of HP based on frequency domain indexes was performed considering the high-frequency (0.15 – 0.45 Hz) components. To compute the CRC, the linear association between HP and RESP series was determined via squared coherence function and directionality of interaction was investigated through the causal extension of this approach. The exercise capacity was assessed through incremental cardiopulmonary exercise testing in order to determine the VO_2peak.

Results

Traditional analysis of HP based on high-frequency index was not correlated with exercise capacity in the athletes (r = −0.1, p = 0.5) and non-athletes (r = −0.1, p = 0.3) cohorts. However, resting CRC values was associated with exercise capacity in athletes (r = 0.4, p = 0.03), but not in the non-athletes group (r = −0.2, p = 0.3).

Conclusion

These results suggest that improved resting values of CRC is associated with higher exercise capacity (VO_2peak) in endurance athletes. Moreover, frequency domain of HP was not sensitive to identifying this relationship, probably because effects of training on parasympathetic modulation might be affected by respiratory dynamics, and this influence has a directionality (i.e., from RESP to HP).