Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2024-01-01 DOI:10.2174/0109298665267989231024064200

Yuting Yang, Wenxin Zhang, Kun Wei, Fei Hu, Song Wu, Yuan Ma, Qing Ouyang

引用次数: 0

Abstract

Neurotensin (NTS) and its receptors (NTSRs) have long been the subject of study and have shown to have a vital function in a variety of systems. They are specifically implicated in the development of tumors and have both oncogenic and anti-apoptotic effects. Neurotensin receptor 2 (NTSR2), like NTSR1, belongs to the G protein-coupled receptor family and has been linked to analgesia, mental disorders, and hematological cancers. However, several research reports have revealed that it exists in numerous different systems. As a result, it seems to be an extremely promising therapeutic target for a variety of diseases. As NTSR2 is particularly prevalent in the brain and has different distribution and developmental characteristics from NTSR1, it may play a specific role in the nervous system. The present review summarizes the expression and function of NTSR2 in different systems, to highlight its potential as a diagnostic tool or therapeutic target.

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NTSR2在几种器官和疾病中的生理病理作用(综述)。

神经紧张素(NTS)及其受体(NTSRs)长期以来一直是研究的主题，并已证明在各种系统中具有重要功能。它们与肿瘤的发展有特殊的关系，具有致癌和抗细胞凋亡的作用。神经紧张素受体2 (NTSR2)与NTSR1一样，属于G蛋白偶联受体家族，与镇痛、精神障碍和血液学癌症有关。然而，一些研究报告显示，它存在于许多不同的系统中。因此，它似乎是一种非常有希望的治疗多种疾病的靶点。由于NTSR2在大脑中尤为普遍，并且与NTSR1具有不同的分布和发育特征，因此它可能在神经系统中发挥特定的作用。本文综述了NTSR2在不同系统中的表达和功能，以突出其作为诊断工具或治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis