Exploring the Cell Wall and Secretory Proteins of Mycobacterium leprae as Biomarkers.

IF 1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sakshi Singh, Devesh Sharma, Sakshi Gautam, Mamta Arora, Deepa Bisht
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引用次数: 0

Abstract

The bacterial cell wall is composed of a wide variety of intricate proteins in addition to lipids, glycolipids, and polymers. Given the diversity of cell wall proteins among bacterial species, they are a feasible target for biomarker identification and characterization in clinical research and diagnosis of the disease. The slow growth rate of Mycobacterium leprae poses a major hurdle in the accurate diagnosis of leprosy before the onset of peripheral neuropathy. The use of biomarker- based diagnostic methods can help in preventing the spread and manifestation of leprosy. Despite many advances in research methods and techniques, there remains a knowledge gap regarding the cell wall proteomes of M. leprae that can be used as biomarkers. The cell wall and secretory proteins of M. leprae are the major focus of this review article. This article enfolds the characteristics and functions of M. leprae cell wall proteins and gives an insight into those cell wall proteins that are yet to be established as biomarkers. Tools and techniques used in cell wall extraction and biomarker identification can also be explored in this article.

探索麻风分枝杆菌细胞壁和分泌蛋白作为生物标志物。
细菌细胞壁除了脂质、糖脂质和聚合物外,还由多种复杂的蛋白质组成。鉴于细菌种类之间细胞壁蛋白的多样性,它们是临床研究和疾病诊断中生物标志物鉴定和表征的可行靶点。麻风分枝杆菌生长速度缓慢,这是在周围神经病变发病前准确诊断麻风的主要障碍。使用基于生物标志物的诊断方法可以帮助预防麻风病的传播和表现。尽管在研究方法和技术方面取得了许多进展,但关于麻风分枝杆菌细胞壁蛋白质组学可作为生物标志物的知识差距仍然存在。本文就麻风分枝杆菌的细胞壁和分泌蛋白作一综述。本文介绍了麻风分枝杆菌细胞壁蛋白的特征和功能,并对尚未确定为生物标志物的细胞壁蛋白进行了深入研究。用于细胞壁提取和生物标志物鉴定的工具和技术也可以在本文中进行探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Protein and Peptide Letters
Protein and Peptide Letters 生物-生化与分子生物学
CiteScore
2.90
自引率
0.00%
发文量
98
审稿时长
2 months
期刊介绍: Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis
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